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1. (n.) thalidomide
a crystalline, slightly water-soluble solid, C
Etymology: (1955–60;
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| Definition of 'thalidomide' |
Princeton's WordNet |
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1. (noun) thalidomide
a sedative and hypnotic drug; withdrawn from sale after discovered to cause severe birth defects because it inhibits angiogenesis
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| Definition of 'thalidomide' |
U.S. National Library of Medicine |
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1. thalidomide
A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppresive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
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