What does thalassemia mean?

Definitions for thalassemia
ˌθæl əˈsi mi ətha·lassemi·a

This dictionary definitions page includes all the possible meanings, example usage and translations of the word thalassemia.

Princeton's WordNet

  1. thalassemia, thalassaemia, Mediterranean anemia, Mediterranean anaemianoun

    an inherited form of anemia caused by faulty synthesis of hemoglobin

Wiktionary

  1. thalassemianoun

    Any of a group of inherited disorders in which the amount of hemoglobin in the blood is reduced

  2. Etymology: From the Greek thalasso- ("sea") and -emia ("blood")αἷμα. The etymology indicates the epidemiology of the disorder in that it commonly occurs in patients of Mediterranean descent. The term was first used in 1932.

Wikipedia

  1. Thalassemia

    Thalassemias are inherited blood disorders characterized by decreased hemoglobin production. Symptoms depend on the type and can vary from none to severe. Often there is mild to severe anemia (low red blood cells or hemoglobin). Anemia can result in feeling tired and pale skin. There may also be bone problems, an enlarged spleen, yellowish skin, and dark urine. Slow growth may occur in children.Thalassemias are genetic disorders inherited from a person's parents. There are two main types, alpha thalassemia and beta thalassemia. The severity of alpha and beta thalassemia depends on how many of the four genes for alpha globin or two genes for beta globin are missing. Diagnosis is typically by blood tests including a complete blood count, special hemoglobin tests, and genetic tests. Diagnosis may occur before birth through prenatal testing.Treatment depends on the type and severity. Treatment for those with more severe disease often includes regular blood transfusions, iron chelation, and folic acid. Iron chelation may be done with deferoxamine, deferasirox or deferiprone. Occasionally, a bone marrow transplant may be an option. Complications may include iron overload from the transfusions with resulting heart or liver disease, infections, and osteoporosis. If the spleen becomes overly enlarged, surgical removal may be required.As of 2015, thalassemia occurs in about 280 million people, with about 439,000 having severe disease. It is most common among people of Italian, Greek, Middle Eastern, South Asian, and African descent. Males and females have similar rates of disease. It resulted in 16,800 deaths in 2015, down from 36,000 deaths in 1990. Those who have minor degrees of thalassemia, similar to those with sickle-cell trait, have some protection against malaria, explaining why they are more common in regions of the world where malaria exists.

ChatGPT

  1. thalassemia

    Thalassemia is a group of inherited blood disorders characterized by reduced or absent levels of hemoglobin, a protein in red blood cells that carries oxygen to the body's tissues. This reduction or absence can result in varying degrees of anemia, potentially causing pale skin, weakness, fatigue, and more serious complications. There are different types of thalassemia, including beta thalassemia and alpha thalassemia, which are determined by which part of the hemoglobin molecule is affected. The severity varies depending on the variations inherited from parents.

Wikidata

  1. Thalassemia

    Thalassemia are forms of inherited autosomal recessive blood disorders that originated in the Mediterranean region. In thalassemia, the disease is caused by the weakening and destruction of red blood cells. Thalassemia is caused by variant or missing genes that affect how the body makes hemoglobin. Hemoglobin is the protein in red blood cells that carries oxygen. People with thalassemia make less hemoglobin and fewer circulating red blood cells than normal, which results in mild or severe anemia. Thalassemia will present as microcytic anemia which may be differentiated from iron deficiency anemia using the mentzer index calculation. Thalassemia can cause significant complications, including iron overload, bone deformities and cardiovascular illness. However this same inherited disease of red blood cells may confer a degree of protection against malaria, which is or was prevalent in the regions where the trait is common. This selective survival advantage on carriers may be responsible for perpetuating the mutation in populations. In that respect, the various thalassemias resemble another genetic disorder affecting hemoglobin, sickle-cell disease.

U.S. National Library of Medicine

  1. Thalassemia

    A group of hereditary hemolytic anemias in which there is decreased synthesis of one or more hemoglobin polypeptide chains. There are several genetic types with clinical pictures ranging from barely detectable hematologic abnormality to severe and fatal anemia.

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Numerology

  1. Chaldean Numerology

    The numerical value of thalassemia in Chaldean Numerology is: 4

  2. Pythagorean Numerology

    The numerical value of thalassemia in Pythagorean Numerology is: 9

Examples of thalassemia in a Sentence

  1. Alexis Thompson:

    The things that I would note, however, are that one needs to evaluate the overall cost of patients who undergo sibling transplants and see if it is comparable, when we look at what the alternative might be -- having a stem cell transplant of any kind -- that is one number that has to be borne in mind. The second is looking at what the costs are for annual care for individuals with thalassemia.

  2. Alexis Thompson:

    When we look at what the alternative might be -- having a stem cell transplant of any kind -- that is one number that has to be borne in mind. The second is looking at what the costs are for annual care for individuals with thalassemia.

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"thalassemia." Definitions.net. STANDS4 LLC, 2024. Web. 28 Mar. 2024. <https://www.definitions.net/definition/thalassemia>.

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