Definitions for temozolomide
temo·zolo·mide

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1. temozolomidenoun

   A particular drug used to treat brain tumors.

WikipediaRate this definition:0.0 / 0 votes

1. Temozolomide

   Temozolomide (TMZ), sold under the brand name Temodar among others, is a medication used to treat brain tumors such as glioblastoma and anaplastic astrocytoma. It is taken by mouth or via intravenous infusion.The most common side effects with temozolomide are nausea, vomiting, constipation, loss of appetite, alopecia (hair loss), headache, fatigue, convulsions (seizures), rash, neutropenia or lymphopenia (low white-blood-cell counts), and thrombocytopenia (low blood platelet counts). People receiving the solution for infusion may also have injection-site reactions, such as pain, irritation, itching, warmth, swelling and redness, as well as bruising.Temozolomide is an alkylating agent used to treat serious brain cancers; most commonly as second-line treatments for astrocytoma and as the first-line treatment for glioblastoma. Olaparib in combination with temozolomide demonstrated substantial clinical activity in relapsed small cell lung cancer.

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1. Temozolomide

   Temozolomide is an oral alkylating agent used for the treatment of Grade IV astrocytoma — an aggressive brain tumor, also known as glioblastoma multiforme — as well as for treating melanoma, a form of skin cancer. Temozolomide is also indicated for relapsed Grade III anaplastic astrocytoma and not indicated for, but as of 2011 used to treat oligodendroglioma brain tumors in some countries, replacing the older PCV regimen. The agent was developed by Malcolm Stevens and his team at Aston University in Birmingham, A derivative of imidazotetrazine, temozolomide is the prodrug of MTIC. It has been available in the US since August 1999, and in other countries since the early 2000s. The therapeutic benefit of temozolomide depends on its ability to alkylate/methylate DNA, which most often occurs at the N-7 or O-6 positions of guanine residues. This methylation damages the DNA and triggers the death of tumor cells. However, some tumor cells are able to repair this type of DNA damage, and therefore diminish the therapeutic efficacy of temozolomide, by expressing a protein called O-6-methylguanine-DNA methyltransferase or O-6-alkylguanine-DNA alkyltransferase. In some tumors, epigenetic silencing of the MGMT/AGT gene prevents the synthesis of this enzyme, and as a consequence such tumors are more sensitive to killing by temozolomide. Conversely, the presence of MGMT protein in brain tumors predicts poor response to temozolomide and these patients receive little benefit from chemotherapy with temozolomide.

How to pronounce temozolomide?

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Numerology

1. Chaldean Numerology

   The numerical value of temozolomide in Chaldean Numerology is: 4

2. Pythagorean Numerology

   The numerical value of temozolomide in Pythagorean Numerology is: 8

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References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Temozolomide
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Temozolomide
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=temozolomide