Definitions for tdp-43 proteinopathies
This page provides all possible meanings and translations of the word tdp-43 proteinopathies
U.S. National Library of Medicine
Diseases characterized by the presence of abnormally phosphorylated, ubiquitinated, and cleaved DNA-binding protein TDP-43 in affected brain and spinal cord. Inclusions of the pathologic protein in neurons and glia, without the presence of AMYLOID, is the major feature of these conditions, thus making these proteinopathies distinct from most other neurogenerative disorders in which protein misfolding leads to brain amyloidosis. Both frontotemporal lobar degeneration and AMYOTROPHIC LATERAL SCLEROSIS exhibit this common method of pathogenesis and thus they may represent two extremes of a continuous clinicopathological spectrum of one disease.
The numerical value of tdp-43 proteinopathies in Chaldean Numerology is: 1
The numerical value of tdp-43 proteinopathies in Pythagorean Numerology is: 5
Images & Illustrations of tdp-43 proteinopathies
Find a translation for the tdp-43 proteinopathies definition in other languages:
Select another language:
Discuss these tdp-43 proteinopathies definitions with the community:
Word of the Day
Would you like us to send you a FREE new word definition delivered to your inbox daily?
Use the citation below to add this definition to your bibliography:
"tdp-43 proteinopathies." Definitions.net. STANDS4 LLC, 2017. Web. 26 Feb. 2017. <http://www.definitions.net/definition/tdp-43 proteinopathies>.