Definitions for tdp-43 proteinopathies
This page provides all possible meanings and translations of the word tdp-43 proteinopathies
U.S. National Library of Medicine
Diseases characterized by the presence of abnormally phosphorylated, ubiquitinated, and cleaved DNA-binding protein TDP-43 in affected brain and spinal cord. Inclusions of the pathologic protein in neurons and glia, without the presence of AMYLOID, is the major feature of these conditions, thus making these proteinopathies distinct from most other neurogenerative disorders in which protein misfolding leads to brain amyloidosis. Both frontotemporal lobar degeneration and AMYOTROPHIC LATERAL SCLEROSIS exhibit this common method of pathogenesis and thus they may represent two extremes of a continuous clinicopathological spectrum of one disease.
Find a translation for the tdp-43 proteinopathies definition in other languages:
Select another language:
Discuss these tdp-43 proteinopathies definitions with the community:
Use the citation below to add this definition to your bibliography:
"tdp-43 proteinopathies." Definitions.net. STANDS4 LLC, 2014. Web. 22 Oct. 2014. <http://www.definitions.net/definition/tdp-43 proteinopathies>.