U.S. National Library of Medicine
Diseases characterized by the presence of abnormally phosphorylated, ubiquitinated, and cleaved DNA-binding protein TDP-43 in affected brain and spinal cord. Inclusions of the pathologic protein in neurons and glia, without the presence of AMYLOID, is the major feature of these conditions, thus making these proteinopathies distinct from most other neurogenerative disorders in which protein misfolding leads to brain amyloidosis. Both frontotemporal lobar degeneration and AMYOTROPHIC LATERAL SCLEROSIS exhibit this common method of pathogenesis and thus they may represent two extremes of a continuous clinicopathological spectrum of one disease.
The numerical value of tdp-43 proteinopathies in Chaldean Numerology is: 1
The numerical value of tdp-43 proteinopathies in Pythagorean Numerology is: 5
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"tdp-43 proteinopathies." Definitions.net. STANDS4 LLC, 2017. Web. 28 May 2017. <http://www.definitions.net/definition/tdp-43 proteinopathies>.