Definitions for tangier disease
This page provides all possible meanings and translations of the word tangier disease
Tangier disease or Hypoalphalipoproteinemia is a rare inherited disorder characterized by a severe reduction in the amount of high density lipoprotein, often referred to as "good cholesterol," in the bloodstream.
U.S. National Library of Medicine
An autosomal recessively inherited disorder caused by mutation of ATP-BINDING CASSETTE TRANSPORTERS involved in cellular cholesterol removal (reverse-cholesterol transport). It is characterized by near absence of ALPHA-LIPOPROTEINS (high-density lipoproteins) in blood. The massive tissue deposition of cholesterol esters results in HEPATOMEGALY; SPLENOMEGALY; RETINITIS PIGMENTOSA; large orange tonsils; and often sensory POLYNEUROPATHY. The disorder was first found among inhabitants of Tangier Island in the Chesapeake Bay, MD.
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"tangier disease." Definitions.net. STANDS4 LLC, 2013. Web. 9 Dec. 2013. <http://www.definitions.net/definition/tangier disease>.