What does tamoxifen mean?

Definitions for tamoxifentəˈmɒk sə fən, -ˌfɛn

Here are all the possible meanings and translations of the word tamoxifen.

Princeton's WordNet

  1. estrogen antagonist, tamoxifen(noun)

    an antagonist for estrogen that is used in the treatment of breast cancer


  1. tamoxifen(Noun)

    A nonsteroidal estrogen antagonist used in the treatment of advanced breast cancer


  1. Tamoxifen

    Tamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, hydroxytamoxifen. In other tissues such as the endometrium, it behaves as an agonist, and thus may be characterized as a mixed agonist/antagonist. Tamoxifen is the usual endocrine therapy for hormone receptor-positive breast cancer in pre-menopausal women, and is also a standard in post-menopausal women although aromatase inhibitors are also frequently used in that setting. Some breast cancer cells require estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen is metabolized into compounds that also bind to the estrogen receptor but do not activate it. Because of this competitive antagonism, tamoxifen acts like a key broken off in the lock that prevents any other key from being inserted, preventing estrogen from binding to its receptor. Hence breast cancer cell growth is blocked. Tamoxifen was discovered by pharmaceutical company Imperial Chemical Industries and is sold under the trade names Nolvadex, Istubal, and Valodex. However, the drug, even before its patent expiration, was and still is widely referred to by its generic name "tamoxifen."

U.S. National Library of Medicine

  1. Tamoxifen

    One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.


  1. Chaldean Numerology

    The numerical value of tamoxifen in Chaldean Numerology is: 4

  2. Pythagorean Numerology

    The numerical value of tamoxifen in Pythagorean Numerology is: 8

Images & Illustrations of tamoxifen

  1. tamoxifentamoxifentamoxifen


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