What does tamoxifen mean?
Definitions for tamoxifen
təˈmɒk sə fən, -ˌfɛnta·mox·ifen
This dictionary definitions page includes all the possible meanings, example usage and translations of the word tamoxifen.
Princeton's WordNet
estrogen antagonist, tamoxifennoun
an antagonist for estrogen that is used in the treatment of breast cancer
Wiktionary
tamoxifennoun
A nonsteroidal estrogen antagonist used in the treatment of advanced breast cancer
Wikipedia
Tamoxifen
Tamoxifen, sold under the brand name Nolvadex among others, is a selective estrogen receptor modulator used to prevent breast cancer in women and treat breast cancer in women and men. It is also being studied for other types of cancer. It has been used for Albright syndrome. Tamoxifen is typically taken daily by mouth for five years for breast cancer.Serious side effects include a small increased risk of uterine cancer, stroke, vision problems, and pulmonary embolism. Common side effects include irregular periods, weight loss, and hot flashes. It may cause harm to the baby if taken during pregnancy or breastfeeding. It is a selective estrogen-receptor modulator (SERM) and works by decreasing the growth of breast cancer cells. It is a member of the triphenylethylene group of compounds.Tamoxifen was initially made in 1962, by chemist Dora Richardson. It is on the World Health Organization's List of Essential Medicines. Tamoxifen is available as a generic medication. In 2020, it was the 317th most commonly prescribed medication in the United States, with more than 900 thousand prescriptions.
ChatGPT
tamoxifen
Tamoxifen is a medication primarily used in the treatment and prevention of breast cancer. It is classified as a selective estrogen receptor modulator (SERM) which functions by binding to estrogen receptors, subsequently blocking estrogen's effects, as certain types of breast cancer require estrogen to grow. It is often used in hormone receptor-positive breast cancers (those that are estrogen or progesterone receptor-positive). Tamoxifen can also be used to decrease the risk of developing breast cancer in those who are at high risk.
Wikidata
Tamoxifen
Tamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, hydroxytamoxifen. In other tissues such as the endometrium, it behaves as an agonist, and thus may be characterized as a mixed agonist/antagonist. Tamoxifen is the usual endocrine therapy for hormone receptor-positive breast cancer in pre-menopausal women, and is also a standard in post-menopausal women although aromatase inhibitors are also frequently used in that setting. Some breast cancer cells require estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen is metabolized into compounds that also bind to the estrogen receptor but do not activate it. Because of this competitive antagonism, tamoxifen acts like a key broken off in the lock that prevents any other key from being inserted, preventing estrogen from binding to its receptor. Hence breast cancer cell growth is blocked. Tamoxifen was discovered by pharmaceutical company Imperial Chemical Industries and is sold under the trade names Nolvadex, Istubal, and Valodex. However, the drug, even before its patent expiration, was and still is widely referred to by its generic name "tamoxifen."
U.S. National Library of Medicine
Tamoxifen
One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.
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Numerology
Chaldean Numerology
The numerical value of tamoxifen in Chaldean Numerology is: 4
Pythagorean Numerology
The numerical value of tamoxifen in Pythagorean Numerology is: 8
Examples of tamoxifen in a Sentence
If a woman becomes post-menopausal during those five or 10 years she’s on tamoxifen, we will switch her to this other group of drugs that is 20 to 25 percent more effective.
The way tamoxifen works is you’re depriving your cancer cells of estrogen, which is their nutrition, so that will only work for the cancers that are estrogen-fed or progesterone-fed.
I discussed it with my doctor, and … we both decided that I would go off of the Tamoxifen, and I’m feeling better all the time, i’m very lucky that so far, so good.
Patients willsay I started taking tamoxifen and I gained 40 pounds, but that’s probably a combination of hormonal and lifestyle changes they’re going through. Tamoxifen can cause some fluid retention, and it could maybe cause a 2- or 3-pound weight gain, but beyond that there are probably other things going on as well.
But that’s probably a combination of hormonal and lifestyle changes they’re going through. Tamoxifen can cause some fluid retention, and it could maybe cause a 2- or 3-pound weight gain, but beyond that there are probably other things going on as well.
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"tamoxifen." Definitions.net. STANDS4 LLC, 2024. Web. 17 Apr. 2024. <https://www.definitions.net/definition/tamoxifen>.
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