An immunosuppressive drug used mainly after organ transplantation.
Origin: From tsukuba macrolide immunosuppressant (after Streptomyces tsukubaensis).
Tacrolimus is an immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection. It is also used in a topical preparation in the treatment of atopic dermatitis, severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease, and the skin condition vitiligo. It is a 23-membered macrolide lactone discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. It reduces interleukin-2 production by T-cells.
U.S. National Library of Medicine
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
The numerical value of tacrolimus in Chaldean Numerology is: 7
The numerical value of tacrolimus in Pythagorean Numerology is: 5
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