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1. (n.) subacute sclerosing panencephalitis
an infection of the central nervous system caused by the measles virus, occurring in children and adolescents several years after a measles attack and characterized by progressive personality changes, seizures, and muscular incoordination.
Etymology: (1950)
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| Definition of 'subacute sclerosing panencephalitis' |
Princeton's WordNet |
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1. (noun) subacute sclerosing panencephalitis, SSPE, inclusion body encephalitis, subacute inclusion body encephalitis, sclerosing leukoencephalitis, subacute sclerosing leukoencephalitis, Bosin's disease, Dawson's encephalitis, Van Bogaert encephalitis
a rare chronic progressive encephalitis caused by the measles virus and occurring primarily in children and young adults; death usually occurs within three years; characterized by primary measles infection before the age of two years
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| Definition of 'subacute sclerosing panencephalitis' |
U.S. National Library of Medicine |
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1. subacute sclerosing panencephalitis
A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8)
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Definitions of subacute sclerosing panencephalitis 
