What does squalamine mean?
Definitions for squalamine
squalamine
This dictionary definitions page includes all the possible meanings, example usage and translations of the word squalamine.
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Wiktionary
squalaminenoun
A broad-spectrum antibiotic derived from the livers of dogfish
Wikipedia
Squalamine
Squalamine is a steroid-polyamine conjugate compound with broad spectrum antimicrobial activity and anti-angiogenic activity. It was studied as a potential cancer drug and as a potential treatment for wet macular degeneration but as of 2018 had not succeeded in Phase III trials for any use.
Wikidata
Squalamine
Squalamine is an aminosterol compound with potent broad spectrum antimicobial activity discovered in the tissues of the dogfish shark by a team led by Dr. Michael Zasloff Dr. Zasloff searched the tissues of the dogfish for compounds that might help explain the hardiness of this animal to infection, despite its "primitive" immune system. Using techniques that Zasloff's team had developed to isolate and identify antimicrobial peptides from animal tissues, the team extracted and characterized a novel bile acid like compound containing a polyamine, never before seen in nature. The compound was called "squalamine", based on its source, and its chemical structure. Further analyses of larger quantities of dogfish liver extracts revealed squalamine to be the most abundant member of a larger aminosterol family, comprising at least 12 related compounds. One of these, "MSI-1436" or "Trodusquamine", although structurally similar to squalamine, and also quite potent as an anti-infective, exhibits a profoundly different pharmacology in vertebrates, causing weight loss and adipose tissue mobilization. Squalamine is sometimes confused with the similar sounding squalene, an unrelated compound also found in shark-liver.
Numerology
Chaldean Numerology
The numerical value of squalamine in Chaldean Numerology is: 3
Pythagorean Numerology
The numerical value of squalamine in Pythagorean Numerology is: 4
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"squalamine." Definitions.net. STANDS4 LLC, 2024. Web. 25 Apr. 2024. <https://www.definitions.net/definition/squalamine>.
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