What does sickle-cell disease mean?
Definitions for sickle-cell disease
sick·le-cel·l dis·ease
This dictionary definitions page includes all the possible meanings, example usage and translations of the word sickle-cell disease.
Princeton's WordNet
sickle-cell anemia, sickle-cell anaemia, sickle-cell disease, crescent-cell anemia, crescent-cell anaemia, drepanocytic anemia, drepanocytic anaemianoun
a congenital form of anemia occurring mostly in blacks; characterized by abnormal blood cells having a crescent shape
Wiktionary
sickle-cell diseasenoun
A disease characterized by sickle-shaped red blood cells.
Wikipedia
sickle-cell disease
Sickle cell disease (SCD) is a group of blood disorders typically inherited. The most common type is known as sickle cell anaemia. It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. This leads to a rigid, sickle-like shape under certain circumstances. Problems in sickle cell disease typically begin around 5 to 6 months of age. A number of health problems may develop, such as attacks of pain (known as a sickle cell crisis), anemia, swelling in the hands and feet, bacterial infections and stroke. Long-term pain may develop as people get older. The average life expectancy in the developed world is 40 to 60 years.Sickle cell disease occurs when a person inherits two abnormal copies of the β-globin gene (HBB) that makes haemoglobin, one from each parent. This gene occurs in chromosome 11. Several subtypes exist, depending on the exact mutation in each haemoglobin gene. An attack can be set off by temperature changes, stress, dehydration, and high altitude. A person with a single abnormal copy does not usually have symptoms and is said to have sickle cell trait. Such people are also referred to as carriers. Diagnosis is by a blood test, and some countries test all babies at birth for the disease. Diagnosis is also possible during pregnancy.The care of people with sickle cell disease may include infection prevention with vaccination and antibiotics, high fluid intake, folic acid supplementation, and pain medication. Other measures may include blood transfusion and the medication hydroxycarbamide (hydroxyurea). A small percentage of people can be cured by a transplant of bone marrow cells.As of 2015, about 4.4 million people have sickle cell disease, while an additional 43 million have sickle cell trait. About 80% of sickle cell disease cases are believed to occur in Sub-Saharan Africa. It also occurs to a lesser degree in parts of India, Southern Europe, West Asia, North Africa and among people of African origin (sub-Saharan) living in other parts of the world. In 2015, it resulted in about 114,800 deaths. The condition was first described in the medical literature by American physician James B. Herrick in 1910. In 1949, its genetic transmission was determined by E. A. Beet and J. V. Neel. In 1954, the protective effect against malaria of sickle cell trait was described.
ChatGPT
sickle-cell disease
Sickle-cell disease is a group of inherited genetic disorders that affects the red blood cells' shape, reducing their flexibility and causing them to assume a rigid, sickle-like shape. This abnormality can result in various complications, including anemia, pain, frequent infections, and delayed growth and development in children. The disease is most common among those of African descent but can also affect people of Middle Eastern, Indian, Mediterranean, and South American descent.
Matched Categories
Numerology
Chaldean Numerology
The numerical value of sickle-cell disease in Chaldean Numerology is: 8
Pythagorean Numerology
The numerical value of sickle-cell disease in Pythagorean Numerology is: 9
Translations for sickle-cell disease
From our Multilingual Translation Dictionary
- enfermedad de célula falciformeSpanish
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"sickle-cell disease." Definitions.net. STANDS4 LLC, 2024. Web. 23 May 2024. <https://www.definitions.net/definition/sickle-cell+disease>.
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