Definitions for ribonucleoproteinˌraɪ boʊˌnu kli oʊˈproʊ tin, -ti ɪn, -ˌnyu-
Random House Webster's College Dictionary
ri•bo•nu•cle•o•pro•teinˌraɪ boʊˌnu kli oʊˈproʊ tin, -ti ɪn, -ˌnyu-(n.)
a substance composed of RNA in close association with protein; a nucleoprotein containing RNA.
Ref: Abbr.: RNP
Origin of ribonucleoprotein:
Any nucleoprotein that contains RNA
Ribonucleoprotein is a nucleoprotein that contains RNA, i.e. it is an association that combines ribonucleic acid and protein together. A few known examples include the ribosome, the enzyme telomerase, vault ribonucleoproteins, RNase P, hnRNP and small nuclear RNPs, which are implicated in pre-mRNA splicing and are among the main components of the nucleolus. 'RNP' can also refer to ribonucleoprotein particles, distinct intracellular foci for post-transcriptional regulation. RNP in snRNPs has an RNA-binding motif in its RNA-binding protein. Aromatic amino acid residues in this motif result in stacking interactions with RNA. Lysine residues in the helical portion of RNA-binding proteins help to stabilize interactions with nucleic acids. This nucleic acid binding is strengthened by electrostatic attraction between the positive lysine side chains and the negative nucleic acid phosphate backbones. RNPs play an important role in influenzavirus A replication. The viral RNA is transcribed into mRNAs by the RNA polymerase attached to the RNPs.
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