Definitions for ribavirinˈraɪ bəˌvaɪ rɪn
This page provides all possible meanings and translations of the word ribavirin
Random House Webster's College Dictionary
ri•ba•vi•rinˈraɪ bəˌvaɪ rɪn(n.)
a synthetic compound, C8H12N4O5, active against several DNA and RNA viruses.
Origin of ribavirin:
1965–70; prob. by shortening and alter. of ribofuranosyl, a component of its chemical name (see ribose , furan , -ose2, -yl ) +vir (us ) + -in1
an inhaled antiviral agent (trade name Virazole) that may be used to treat serious virus infections
An antiviral drug used to treat a number of DNA and RNA viruses.
Ribavirin is a guanosine analog used to stop viral RNA synthesis and viral mRNA capping; simply put, it is a nucleoside inhibitor. Its brand names include Copegus, Rebetol, Ribasphere, Vilona, and Virazole, and it is an anti-viral drug indicated for severe RSV infection, hepatitis C infection, and some other viral infections. Ribavirin is a prodrug, which when metabolized resembles purine RNA nucleotides. In this form it interferes with RNA metabolism required for viral replication. How it exactly affects viral replication is unknown; many mechanisms have been proposed for this but none of these has been proven to date. Multiple mechanisms may be responsible for its actions. The primary observed serious adverse side effect of ribavirin is hemolytic anemia, which may worsen preexisting cardiac disease. The mechanism for this effect is due to ribavirin's buildup inside erythrocytes. Oxidative damage to erythrocyte cell membrane is usually inhibited by glutathione; however, with reduced ATP levels caused by ribavirin, glutathione levels are impaired, permitting oxidative erythrocyte cell lysis. The gradual loss of erythrocytes leads to anemia. The anemia is dose-dependent and may sometimes be compensated by decreasing dose. Ribavirin is also a teratogen in some animals species and thus poses a theoretical reproductive risk in humans, remaining a hazard as long as the drug is present, which can be as long as 6 months after a course of the drug has ended.
U.S. National Library of Medicine
A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.
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