Definitions for quisqualic acid

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  1. Quisqualic acid

    Quisqualic acid is an agonist for both AMPA receptors and group I metabotropic glutamate receptors. It causes excitotoxicity and is used in neuroscience to selectively destroy neurons in the brain or spinal cord. It occurs naturally in the seeds of Quisqualis species.[α] 20D = +17 Research conducted by the USDA Agricultural Research Service, has demonstrated quisqualic acid is also present within the flower petals of zonal geranium and is responsible for causing paralysis of the Japanese beetle. Quisqualic acid is thought to mimic L-glutamic acid, which is a neurotransmitter in the insect neuromuscular junction and mammalian central nervous system.

U.S. National Library of Medicine

  1. Quisqualic Acid

    An agonist at two subsets of excitatory amino acid receptors, ionotropic receptors that directly control membrane channels and metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores. The compound is obtained from the seeds and fruit of Quisqualis chinensis.


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