Definitions for quinolinic acid

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Wiktionary

  1. quinolinic acid(Noun)

    Pyridine-2,3-dicarboxylic acid, which may be prepared by the oxidation of quinoline.

Freebase

  1. Quinolinic acid

    Quinolinic acid is a dicarboxylic acid with a pyridine backbone. It may be prepared by the oxidation of quinoline. Quinolinic acid is a downstream product of the kynurenine pathway, which metabolizes the amino acid tryptophan. It acts as an NMDA receptor agonist. Quinolinic acid has a potent neurotoxic effect. Studies have demonstrated that quinolinic acid may be involved in many psychiatric disorders, neurodegenerative processes in the brain, as well as other disorders. Within the brain, quinolinic acid is only produced by activated microglia and macrophages.

U.S. National Library of Medicine

  1. Quinolinic Acid

    A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.

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