Definitions for proteostasis
pro·teosta·sis

WiktionaryRate this definition:0.0 / 0 votes

1. proteostasisnoun

   eukaryotic protein homeostasis

WikipediaRate this definition:0.0 / 0 votes

1. Proteostasis

   Proteostasis is the dynamic regulation of a balanced, functional proteome. The proteostasis network includes competing and integrated biological pathways within cells that control the biogenesis, folding, trafficking, and degradation of proteins present within and outside the cell. Loss of proteostasis is central to understanding the cause of diseases associated with excessive protein misfolding and degradation leading to loss-of-function phenotypes, as well as aggregation-associated degenerative disorders. Therapeutic restoration of proteostasis may treat or resolve these pathologies. Cellular proteostasis is key to ensuring successful development, healthy aging, resistance to environmental stresses, and to minimize homeostatic perturbations from pathogens such as viruses. Cellular mechanisms for maintaining proteostasis include regulated protein translation, chaperone assisted protein folding, and protein degradation pathways. Adjusting each of these mechanisms based on the need for specific proteins is essential to maintain all cellular functions relying on a correctly folded proteome.

WikidataRate this definition:1.0 / 1 vote

1. Proteostasis

   Proteostasis, a portmanteau of the words protein and homeostasis, is the concept that there are competing and integrated biological pathways within cells that control the biogenesis, folding, trafficking and degradation of proteins present within and outside the cell. The concept of proteostasis maintenance is central to understanding the cause of diseases associated with excessive protein misfolding and degradation leading to loss-of-function phenotypes, as well as aggregation-associated degenerative disorders. Therefore, adapting proteostasis should enable the restoration of proteostasis, once its loss leads to pathology. Cellular proteostasis is key to ensuring successful development, healthy aging, resistance to environmental stresses, and to minimize homeostasis perturbations by pathogens such as viruses. Proteostasis in distinct subcellular environments is constantly monitored by stress-responsive signaling pathways unique to those compartments, which match proteostasis capacity to demand employing a transcriptional program and translational attenuation. Transcriptional up- and down-regulation enhances folding and degradation capacity in unison, which is probably critical for maintaining constant protein concentrations required for normal cellular physiology. As such, maintenance of proteostasis prevents disease onset.

How to pronounce proteostasis?

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How to say proteostasis in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of proteostasis in Chaldean Numerology is: 3

2. Pythagorean Numerology

   The numerical value of proteostasis in Pythagorean Numerology is: 5

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Proteostasis
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Proteostasis
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=proteostasis