Definitions for proglucagon

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  1. Proglucagon

    Proglucagon is a protein that in humans is encoded by the GCG gene. Proglucagon is a precursor of glucagon, and several other components. It is generated in the alpha cells of the pancreas and in the intestinal L cells in the distal ileum and colon. It is cleaved into the following components: ⁕Glicentin ⁕Glicentin-related pancreatic polypeptide ⁕Oxyntomodulin ⁕Glucagon ⁕Glucagon-like peptide 1 ⁕Glucagon-like peptide 2

U.S. National Library of Medicine

  1. Proglucagon

    The common precursor polypeptide of pancreatic GLUCAGON and intestinal GLUCAGON-LIKE PEPTIDES. Proglucagon is the 158-amino acid segment of preproglucagon without the N-terminal signal sequence. Proglucagon is expressed in the PANCREAS; INTESTINES; and the CENTRAL NERVOUS SYSTEM. Posttranslational processing of proglucagon is tissue-specific yielding numerous bioactive peptides.

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