Definitions for polyadenylation
po·lyadeny·la·tion

WiktionaryRate this definition:0.0 / 0 votes

1. polyadenylationnoun

   The formation of a polyadenylate, especially that of a nucleic acid

WikipediaRate this definition:0.0 / 0 votes

1. Polyadenylation

   Polyadenylation is the addition of a poly(A) tail to an RNA transcript, typically a messenger RNA (mRNA). The poly(A) tail consists of multiple adenosine monophosphates; in other words, it is a stretch of RNA that has only adenine bases. In eukaryotes, polyadenylation is part of the process that produces mature mRNA for translation. In many bacteria, the poly(A) tail promotes degradation of the mRNA. It, therefore, forms part of the larger process of gene expression. The process of polyadenylation begins as the transcription of a gene terminates. The 3′-most segment of the newly made pre-mRNA is first cleaved off by a set of proteins; these proteins then synthesize the poly(A) tail at the RNA's 3′ end. In some genes these proteins add a poly(A) tail at one of several possible sites. Therefore, polyadenylation can produce more than one transcript from a single gene (alternative polyadenylation), similar to alternative splicing.The poly(A) tail is important for the nuclear export, translation and stability of mRNA. The tail is shortened over time, and, when it is short enough, the mRNA is enzymatically degraded. However, in a few cell types, mRNAs with short poly(A) tails are stored for later activation by re-polyadenylation in the cytosol. In contrast, when polyadenylation occurs in bacteria, it promotes RNA degradation. This is also sometimes the case for eukaryotic non-coding RNAs.mRNA molecules in both prokaryotes and eukaryotes have polyadenylated 3′-ends, with the prokaryotic poly(A) tails generally shorter and fewer mRNA molecules polyadenylated.

WikidataRate this definition:5.0 / 1 vote

1. Polyadenylation

   Polyadenylation is the addition of a poly tail to an RNA molecule. The poly tail consists of multiple adenosine monophosphates; in other words, it is a stretch of RNA that has only adenine bases. In eukaryotes, polyadenylation is part of the process that produces mature messenger RNA for translation. It, therefore, forms part of the larger process of gene expression. The process of polyadenylation begins as the transcription of a gene finishes, or terminates. The 3'-most segment of the newly made RNA is first cleaved off by a set of proteins; these proteins then synthesize the poly tail at the RNA's 3' end. In some genes, these proteins may add a poly tail at any one of several possible sites. Therefore, polyadenylation can produce more than one transcript from a single gene, similar to alternative splicing. The poly tail is important for the nuclear export, translation, and stability of mRNA. The tail is shortened over time, and, when it is short enough, the mRNA is enzymatically degraded. However, in a few cell types, mRNAs with short poly tails are stored for later activation by re-polyadenylation in the cytosol. In contrast, when polyadenylation occurs in bacteria, it promotes RNA degradation. This is also sometimes the case for eukaryotic non-coding RNAs.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Polyadenylation

   The addition of a tail of polyadenylic acid (POLY A) to the 3' end of mRNA (RNA, MESSENGER). Polyadenylation involves recognizing the processing site signal, (AAUAAA), and cleaving of the mRNA to create a 3' OH terminal end to which poly A polymerase (POLYNUCLEOTIDE ADENYLYLTRANSFERASE) adds 60-200 adenylate residues. The 3' end processing of some messenger RNAs, such as histone mRNA, is carried out by a different process that does not include the addition of poly A as described here.

How to pronounce polyadenylation?

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Numerology

1. Chaldean Numerology

   The numerical value of polyadenylation in Chaldean Numerology is: 2

2. Pythagorean Numerology

   The numerical value of polyadenylation in Pythagorean Numerology is: 8

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References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Polyadenylation
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Polyadenylation
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=polyadenylation