Definitions for phagosome
ˈfæg əˌsoʊmphago·some

WiktionaryRate this definition:0.0 / 0 votes

1. phagosomenoun

   A membrane-bound vacuole within a cell containing foreign material captured by phagocytosis.

WikipediaRate this definition:0.0 / 0 votes

1. Phagosome

   In cell biology, a phagosome is a vesicle formed around a particle engulfed by a phagocyte via phagocytosis. Professional phagocytes include macrophages, neutrophils, and dendritic cells (DCs).A phagosome is formed by the fusion of the cell membrane around a microorganism, a senescent cell or an apoptotic cell. Phagosomes have membrane-bound proteins to recruit and fuse with lysosomes to form mature phagolysosomes. The lysosomes contain hydrolytic enzymes and reactive oxygen species (ROS) which kill and digest the pathogens. Phagosomes can also form in non-professional phagocytes, but they can only engulf a smaller range of particles, and do not contain ROS. The useful materials (e.g. amino acids) from the digested particles are moved into the cytosol, and waste is removed by exocytosis. Phagosome formation is crucial for tissue homeostasis and both innate and adaptive host defense against pathogens. However, some bacteria can exploit phagocytosis as an invasion strategy. They either reproduce inside of the phagolysosome (e.g. Coxiella spp.) or escape into the cytoplasm before the phagosome fuses with the lysosome (e.g. Rickettsia spp.). Many Mycobacteria, including Mycobacterium tuberculosis and Mycobacterium avium paratuberculosis, can manipulate the host macrophage to prevent lysosomes from fusing with phagosomes and creating mature phagolysosomes. Such incomplete maturation of the phagosome maintains an environment favorable to the pathogens inside it.

WikidataRate this definition:0.0 / 0 votes

1. Phagosome

   In cell biology, a phagosome is a vesicle formed around a particle absorbed by phagocytosis. The vacuole is formed by the fusion of the cell membrane around the particle. A phagosome is a cellular compartment in which pathogenic microorganisms can be killed and digested. Phagosomes fuse with lysosomes in their maturation process, forming phagolysosomes. Some bacterial pathogens that enter cells inside phagosomes either reproduce inside of the formed phagolysosome or escape into the cytoplasm before the phagosome fuses with the lysosome. Many mycobacteria, including Mycobacterium tuberculosis and Mycobacteria avium paratuberculosis, manipulate the host macrophage to prevent nitrous acid-containing lysosomes from fusing with phagosomes and creating mature phagolysosomes. Such incomplete maturation of the phagosome maintains an environment favorable to the pathogens inside it.

How to pronounce phagosome?

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Numerology

1. Chaldean Numerology

   The numerical value of phagosome in Chaldean Numerology is: 7

2. Pythagorean Numerology

   The numerical value of phagosome in Pythagorean Numerology is: 9

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References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Phagosome
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Phagosome
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=phagosome