Definitions for penetrance
ˈpɛn ɪ trənspen·e·trance

WiktionaryRate this definition:0.0 / 0 votes

1. penetrancenoun

   The proportion of individuals carrying a particular variation of a gene that also express an associated trait

WikipediaRate this definition:0.0 / 0 votes

1. Penetrance

   Penetrance in genetics is the proportion of individuals carrying a particular variant (or allele) of a gene (the genotype) that also expresses an associated trait (the phenotype). In medical genetics, the penetrance of a disease-causing mutation is the proportion of individuals with the mutation that exhibit clinical symptoms among all individuals with such mutation. For example, if a mutation in the gene responsible for a particular autosomal dominant disorder has 95% penetrance, then 95% of those with the mutation will develop the disease, while 5% will not. A condition, most commonly inherited in an autosomal dominant manner, is said to show complete penetrance if clinical symptoms are present in all individuals who have the disease-causing mutation. A condition which shows complete penetrance is neurofibromatosis type 1 – every person who has a mutation in the gene will show symptoms of the condition. The penetrance is 100%.

Webster DictionaryRate this definition:0.0 / 0 votes

1. Penetrancenoun

   alt. of Penetrancy

WikidataRate this definition:0.0 / 0 votes

1. Penetrance

   Penetrance in genetics is the proportion of individuals carrying a particular variant of a gene that also express an associated trait. In medical genetics, the penetrance of a disease-causing mutation is the proportion of individuals with the mutation who exhibit clinical symptoms. For example, if a mutation in the gene responsible for a particular autosomal dominant disorder has 95% penetrance, then 95% of those with the mutation will develop the disease, while 5% will not. Common examples used to show degrees of penetrance are often highly penetrant. There are several reasons for this: ⁕Highly penetrant alleles, and highly heritable symptoms, are easier to demonstrate, because if the allele is present, the phenotype is generally expressed. Mendelian genetic concepts such as recessiveness, dominance, and co-dominance are fairly simple additions to this principle. ⁕Alleles which are highly penetrant are more likely to be noticed by clinicians and geneticists, and alleles for symptoms which are highly heritable are more likely to be inferred to exist, and then are more easily tracked down.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Penetrance

   The percent frequency with which a dominant or homozygous recessive gene or gene combination manifests itself in the phenotype of the carriers. (From Glossary of Genetics, 5th ed)

Anagrams for penetrance »

1. repentance

How to pronounce penetrance?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say penetrance in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of penetrance in Chaldean Numerology is: 7

2. Pythagorean Numerology

   The numerical value of penetrance in Pythagorean Numerology is: 2

Examples of penetrance in a Sentence

1. Anthony Fauci:

   I would back the CDC recommendations because that is really based on data, we didn't fully appreciate that early on. But the fact is that when you look at a community and look at the penetrance of the virus in the community and its spread at the community level, compared to the school in that community, it's less likely for a child to get infected in the school setting than if they were just in the community.

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References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Penetrance
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Penetrance
3. ^ Webster Dictionary
   https://www.merriam-webster.com/dictionary/penetrance
4. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=penetrance