Definitions for pemphigusˈpɛm fɪ gəs, pɛmˈfaɪ-
This page provides all possible meanings and translations of the word pemphigus
a skin disease characterized by large thin-walled blisters (bullae) arising from normal skin or mucous membrane
A severe autoimmune skin disease characterized by pustules and painful blisters, and which can be fatal.
Origin: From πέμφιξ.
a somewhat rare skin disease, characterized by the development of blebs upon different part of the body
Pemphigus is a rare group of blistering autoimmune diseases that affect the skin and mucous membranes. In pemphigus, autoantibodies form against desmoglein. Desmoglein forms the "glue" that attaches adjacent epidermal cells via attachment points called desmosomes. When autoantibodies attack desmogleins, the cells become separated from each other and the epidermis becomes "unglued", a phenomenon called acantholysis. This causes blisters that slough off and turn into sores. In some cases, these blisters can cover a significant area of the skin. Originally, the cause of this disease was unknown, and "pemphigus" was used to refer to any blistering disease of the skin and mucosa. In 1964, a historic paper that changed the understanding of pemphigus was published. In 1971, an article investigating the autoimmune nature of this disease was published.
U.S. National Library of Medicine
Group of chronic blistering diseases characterized histologically by ACANTHOLYSIS and blister formation within the EPIDERMIS.
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