What does pegylation mean?
Definitions for pegylation
pe·gy·la·tion
This dictionary definitions page includes all the possible meanings, example usage and translations of the word pegylation.
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Wiktionary
PEGylationnoun
The process of covalent attachment of PEG (polyethylene glycol) polymer chains to another molecule, normally a drug or therapeutic protein.
Wikipedia
PEGylation
PEGylation (or pegylation) is the process of both covalent and non-covalent attachment or amalgamation of polyethylene glycol (PEG, in pharmacy called macrogol) polymer chains to molecules and macrostructures, such as a drug, therapeutic protein or vesicle, which is then described as PEGylated. PEGylation affects the resulting derivatives or aggregates interactions, which typically slows down their coalescence and degradation as well as elimination in vivo.PEGylation is routinely achieved by the incubation of a reactive derivative of PEG with the target molecule. The covalent attachment of PEG to a drug or therapeutic protein can "mask" the agent from the host's immune system (reducing immunogenicity and antigenicity), and increase its hydrodynamic size (size in solution), which prolongs its circulatory time by reducing renal clearance. PEGylation can also provide water solubility to hydrophobic drugs and proteins. Having proven its pharmacological advantages and acceptability, PEGylation technology is the foundation of a growing multibillion-dollar industry.
Wikidata
PEGylation
PEGylation is the process of covalent attachment of polyethylene glycol polymer chains to another molecule, normally a drug or therapeutic protein. PEGylation is routinely achieved by incubation of a reactive derivative of PEG with the target molecule. The covalent attachment of PEG to a drug or therapeutic protein can "mask" the agent from the host's immune system, and increase the hydrodynamic size of the agent which prolongs its circulatory time by reducing renal clearance. PEGylation can also provide water solubility to hydrophobic drugs and proteins.
Numerology
Chaldean Numerology
The numerical value of pegylation in Chaldean Numerology is: 2
Pythagorean Numerology
The numerical value of pegylation in Pythagorean Numerology is: 7
Translations for pegylation
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"pegylation." Definitions.net. STANDS4 LLC, 2024. Web. 23 Apr. 2024. <https://www.definitions.net/definition/pegylation>.
_alternate.svg/220px-Poly(ethylene_glycol)_alternate.svg.png "pegylation")
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