Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. Disturbances in the normal redox state of cells can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell, including proteins, lipids, and DNA. Further, some reactive oxidative species act as cellular messengers in redox signaling. Thus, oxidative stress can cause disruptions in normal mechanisms of cellular signaling. In humans, oxidative stress is thought to be involved in the development of cancer, Parkinson's disease, Alzheimer's disease, atherosclerosis, heart failure, myocardial infarction, fragile X syndrome, Sickle Cell Disease, lichen planus, vitiligo, autism, and chronic fatigue syndrome. However, reactive oxygen species can be beneficial, as they are used by the immune system as a way to attack and kill pathogens. Short-term oxidative stress may also be important in prevention of aging by induction of a process named mitohormesis.
U.S. National Library of Medicine
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
The numerical value of oxidative stress in Chaldean Numerology is: 9
The numerical value of oxidative stress in Pythagorean Numerology is: 2
Sample Sentences & Example Usage
Studies have shown that pollution increases inflammation and oxidative stress, both of which have been linked to increased mortality, those studies weren't done in lung cancer patients, but it is reasonable to think that similar things may be occurring.
As a major natural antioxidant in the body, uric acid has been estimated to account for more than 50 percent of the antioxidant capacity of plasma, with these potentially neuro-protective properties, uric acid has been hypothesized to protect against oxidative stress, a prominent contributor to dopaminergic neuron degeneration in Parkinson's disease, which may also play an important role in the pathogenesis of Alzheimer’s disease.
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- ஆக்ஸிஜனேற்ற அழுத்த நிலைTamil
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"oxidative stress." Definitions.net. STANDS4 LLC, 2017. Web. 25 Apr. 2017. <http://www.definitions.net/definition/oxidative stress>.