osteogenesis imperfecta(noun)

autosomal dominant disorder of connective tissue characterized by brittle bones that fracture easily

osteogenesis imperfecta(Noun)

a hereditary disease characterized by brittle bones that easily fracture

Osteogenesis Imperfecta

Autosomal dominant COLLAGEN DISEASES resulting from defective biosynthesis of COLLAGEN TYPE I and characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. There are four major types, I-IV.