Definitions for osteogenesis imperfecta
os·teo·ge·n·e·sis im·per·fec·ta

Princeton's WordNetRate this definition:0.0 / 0 votes

1. osteogenesis imperfectanoun

   autosomal dominant disorder of connective tissue characterized by brittle bones that fracture easily

WiktionaryRate this definition:0.0 / 0 votes

1. osteogenesis imperfectanoun

   a hereditary disease characterized by brittle bones that easily fracture

ChatGPTRate this definition:0.0 / 0 votes

1. osteogenesis imperfecta

   Osteogenesis imperfecta, sometimes known as "brittle bone disease," is a genetic disorder characterized by fragile bones that break easily. It’s caused by defective genes which affect the body's ability to produce collagen, a protein that helps strengthen bones. Symptoms can range from mild to severe and may also include weak muscles, brittle teeth, and hearing loss. Osteogenesis imperfecta is an inherited condition, usually passed from parent to child.

WikidataRate this definition:5.0 / 1 vote

1. Osteogenesis imperfecta

   Osteogenesis imperfecta is a congenital bone disorder. People with OI are born with defective connective tissue, or without the ability to make it, usually because of a deficiency of Type-I collagen. This deficiency arises from an amino acid substitution of glycine to bulkier amino acids in the collagen triple helix structure. The larger amino acid side-chains create steric hindrance that creates a bulge in the collagen complex, which in turn influences both the molecular nanomechanics as well as the interaction between molecules, which are both compromised. As a result, the body may respond by hydrolyzing the improper collagen structure. If the body does not destroy the improper collagen, the relationship between the collagen fibrils and hydroxyapatite crystals to form bone is altered, causing brittleness. Another suggested disease mechanism is that the stress state within collagen fibrils is altered at the locations of mutations, where locally larger shear forces lead to rapid failure of fibrils even at moderate loads as the homogeneous stress state found in healthy collagen fibrils is lost. These recent works suggest that OI must be understood as a multi-scale phenomenon, which involves mechanisms at the genetic, nano-, micro- and macro-level of tissues.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Osteogenesis Imperfecta

   Autosomal dominant COLLAGEN DISEASES resulting from defective biosynthesis of COLLAGEN TYPE I and characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. There are four major types, I-IV.

Matched Categories

1. • Autosomal Dominant Disease

How to pronounce osteogenesis imperfecta?

1. Alex

   US English

   David

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   Mark

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   Daniel

   British

   Libby

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   Mia

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   Karen

   Australian

   Hayley

   Australian

   Natasha

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   Veena

   Indian

   Priya

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   Neerja

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   Zira

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   Oliver

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   Wendy

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   Tessa

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How to say osteogenesis imperfecta in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of osteogenesis imperfecta in Chaldean Numerology is: 2

2. Pythagorean Numerology

   The numerical value of osteogenesis imperfecta in Pythagorean Numerology is: 5

References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=osteogenesis imperfecta
2. ^ Wiktionary
   https://en.wiktionary.org/wiki/Osteogenesis_Imperfecta
3. ^ ChatGPT
   https://chat.openai.com
4. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=osteogenesis imperfecta