Definitions for orientia tsutsugamushi
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Orientia tsutsugamushi is the causative organism of scrub typhus, and the natural vector and reservoir is probably trombiculid mites. The organism is an obligate intracellular pathogen, which needs to infect eukaryotic cells in order to multiply. The envelope is similar to that of Gram negative bacteria, but it is not easily stained with Gram stain and the Gimenez stain is preferred. There are a large number of serotypes described: these include Karp, Gilliam, Kato, and Kawasaki, but there exists enormous variability, with eight serotypes being reported in a single field in Malaysia, and many more serotypes continue to be reported. Genetic methods have revealed even greater complexity than had been previously described. Infection with one serotype does not confer immunity to other serotypes. Repeated infection in the same individual is therefore possible, and this complicates vaccine design.
U.S. National Library of Medicine
A gram-negative, rod-shaped to coccoid bacterium. It is the etiologic agent of SCRUB TYPHUS in humans and is transmitted by mites from rodent reservoirs.
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