Definitions for oleanolic acid

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Wiktionary

  1. oleanolic acid(Noun)

    A pentacyclic triterpenoid carboxylic acid found in many plants; an isomer of ursolic acid

Freebase

  1. Oleanolic acid

    Oleanolic acid or oleanic acid is a naturally occurring triterpenoid, widely distributed in food and medicinal plants, related to betulinic acid. It can be found in Phytolacca americana, and Syzygium spp, garlic, etc. It is relatively non-toxic, hepatoprotective, and exhibits antitumor and antiviral properties. Oleanolic acid was found to exhibit weak anti-HIV and weak anti-HCV activities, but more potent synthetic analogs are being investigated as potential drugs. It was first studied and isolated from several plants, including Rosa woodsii, Prosopis glandulosa, Phordendron juniperinum, Syzygium claviflorum, Hyptis capitata, and Ternstromia gymnanthera. Other Syzygium species including java apple and rose apples contain it. An extremely potent synthetic triterpenoid analog of oleanolic acid was found in 2005, that is a powerful inhibitor of cellular inflammatory processes. They work by the induction by IFN- of inducible nitric oxide synthase and of cyclooxygenase 2 in mouse macrophages. They are extremely potent inducers of the phase 2 response, which is a major protector of cells against oxidative and electrophile stress.

U.S. National Library of Medicine

  1. Oleanolic Acid

    A pentacyclic triterpene that occurs widely in many PLANTS as the free acid or the aglycone for many SAPONINS. It is biosynthesized from lupane. It can rearrange to the isomer, ursolic acid, or be oxidized to taraxasterol and amyrin.

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