Definitions for ochronosis

This page provides all possible meanings and translations of the word ochronosis

Princeton's WordNet

  1. ochronosis(noun)

    an accumulation of dark pigment in cartilage and other connective tissue; usually a symptom of alkaptonuria or phenol poisoning

Wiktionary

  1. ochronosis(Noun)

    An autosomal-recessive metabolic disorder that causes an excess of homogentisic acid, resulting in adverse pigmentation, calcification, and inflammation of cartilaginous and related tissue throughout the body.

Freebase

  1. Ochronosis

    Ochronosis is the syndrome caused by the accumulation of homogentisic acid in connective tissues. The phenomenon was first described by Rudolf Virchow in 1865. The condition was named after the yellowish discoloration of the tissue seen on microscopic examination. However, macroscopically the affected tissues appear bluish grey because of a light scattering phenomenon known as the Tyndall effect. The condition is most often associated with alkaptonuria but can occur from exogenous administration of phenol complexes like hydroquinone.

U.S. National Library of Medicine

  1. Ochronosis

    The yellowish discoloration of connective tissue due to deposition of HOMOGENTISIC ACID (a brown-black pigment). This is due to defects in the metabolism of PHENYLALANINE and TYROSINE. Ochronosis occurs in ALKAPTONURIA, but has also been associated with exposure to certain chemicals (e.g., PHENOL, trinitrophenol, BENZENE DERIVATIVES).

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"ochronosis." Definitions.net. STANDS4 LLC, 2014. Web. 23 Oct. 2014. <http://www.definitions.net/definition/ochronosis>.

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