What does nicorandil mean?
Definitions for nicorandil
nico·randil
This dictionary definitions page includes all the possible meanings, example usage and translations of the word nicorandil.
Wikidata
Nicorandil
Nicorandil is a vasodilatory drug used to treat angina. It is marketed under the trade names Ikorel, Angedil, Dancor, Nikoran,PCA, Aprior, Nitorubin, and Sigmart. Nicorandil is not available in the United States. Angina is chest pain that results from episodes of transient myocardial ischemia. This can be caused by diseases such as atherosclerosis, coronary artery disease and aortic stenosis. Angina commonly arises from vasospasm of the coronary arteries. There are multiple mechanisms causing the increased smooth muscle contraction involved in coronary vasospasm, including increased Rho-kinase activity. Increased levels of Rho-kinase inhibit myosin phosphatase activity, leading to increased calcium sensitivity and hypercontraction[3]. Rho-kinase also decreases nitric oxide synthase activity, which reduces nitric oxide concentrations[2].Lower levels of nitric oxide are present in spastic coronary arteries[1]. L-type calcium channel expression increases in spastic vascular smooth muscle cells, which could result in excessive calcium influx, and hypercontraction[4].
U.S. National Library of Medicine
Nicorandil
A derivative of the NIACINAMIDE that is structurally combined with an organic nitrate. It is a potassium-channel opener that causes vasodilatation of arterioles and large coronary arteries. Its nitrate-like properties produce venous vasodilation through stimulation of guanylate cyclase.
Numerology
Chaldean Numerology
The numerical value of nicorandil in Chaldean Numerology is: 5
Pythagorean Numerology
The numerical value of nicorandil in Pythagorean Numerology is: 9
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"nicorandil." Definitions.net. STANDS4 LLC, 2024. Web. 24 Apr. 2024. <https://www.definitions.net/definition/nicorandil>.
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