Definitions for niaprazine
niaprazine

WiktionaryRate this definition:0.0 / 0 votes

1. niaprazinenoun

   A particular antihistamine drug derived from piperazine.

WikipediaRate this definition:0.0 / 0 votes

1. Niaprazine

   Niaprazine (INN) (brand name Nopron) is a sedative-hypnotic drug of the phenylpiperazine group. It has been used in the treatment of sleep disturbances since the early 1970s in several European countries including France, Italy, and Luxembourg. It is commonly used with children and adolescents on account of its favorable safety and tolerability profile and lack of abuse potential.Originally believed to act as an antihistamine and anticholinergic, niaprazine was later discovered to have low or no binding affinity for the H1 and mACh receptors (Ki = > 1 μM), and was instead found to act as a potent and selective 5-HT2A and α1-adrenergic receptor antagonist (Ki = 75 nM and 86 nM, respectively). It possesses low or no affinity for the 5-HT1A, 5-HT2B, D2, and β-adrenergic, as well as at SERT and VMAT (Ki = all > 1 μM), but it does have some affinity for the α2-adrenergic receptor (Ki = 730 nM).Niaprazine has been shown to metabolize to the compound para-fluorophenylpiperazine (pFPP) in a similar manner to how trazodone and nefazodone metabolize to meta-chlorophenylpiperazine (mCPP). It is unclear what role, if any, pFPP plays in the clinical effects of niaprazine. However, from animal studies it is known that pFPP, unlike niaprazine, does not produce sedative effects, and instead exerts a behavioral profile indicative of serotonergic activation.

WikidataRate this definition:0.0 / 0 votes

1. Niaprazine

   Niaprazine is a sedative-hypnotic drug of the phenylpiperazine class. It has been used in the treatment of sleep disturbances since the early 1970s in several European countries, including France, Italy, and Luxembourg. It is commonly used with children and adolescents on account of its favorable safety and tolerability profile and lack of abuse potential. Originally believed to act as an antihistamine and anticholinergic, niaprazine was later discovered to have no significant binding affinity for either the H1 or the mACh receptors, and was instead found to act as a potent and selective 5-HT2A and α1-adrenergic receptor antagonist. It is virtually inactive at 5-HT1A, 5-HT2B, D2, and β-adrenergic, as well as at SERT and VMAT, but it does have some weak affinity for the α2-adrenergic receptor, likely acting as an antagonist there as well. Niaprazine has been shown to metabolize to the compound pFPP in a similar manner to how trazodone and nefazodone metabolize to mCPP. It is unclear what role, if any, pFPP plays in the clinical effects of niaprazine. However, from animal studies it is known that pFPP, unlike niaprazine, does not produce sedative effects, and instead exerts a behavioral profile indicative of serotonergic activation.

How to pronounce niaprazine?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say niaprazine in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of niaprazine in Chaldean Numerology is: 9

2. Pythagorean Numerology

   The numerical value of niaprazine in Pythagorean Numerology is: 5

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Niaprazine
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Niaprazine
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=niaprazine