What does neocarzinostatin mean?
Definitions for neocarzinostatin
neo·carzi·no·s·tatin
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Wiktionary
neocarzinostatinnoun
A macromolecular chromoprotein enediyne antibiotic secreted by Streptomyces macromomyceticus.
Wikipedia
Neocarzinostatin
Neocarzinostatin (NCS) is a macromolecular chromoprotein enediyne antitumor antibiotic secreted by Streptomyces macromomyceticus. It consists of two parts, a labile chromophore (the non-protein molecular entity shown at right) and a 113 amino acid protein to which the chromophore is tightly and non-covalently bound with high affinity (Kd ~ 10−10 M). The non-protein component is a very potent DNA-damaging agent; However it is extremely unstable and the role of the protein is to protect it and release it to the target DNA. Opening of the epoxide under reductive conditions present in cells creates favorable conditions for a Masamune-Bergman cyclization, leading to formation of benzyne, followed by DNA strand cleavage. Another important member of the chromoprotein group of natural products is kedarcidin. As a medicine it is among the most potent, and in Japan only it has been used against liver cancer clinically.
Wikidata
Neocarzinostatin
Neocarzinostatin is a macromolecular chromoprotein enediyne antibiotic with anti-tumoral activity secreted by Streptomyces macromomyceticus. It consists of two parts, a labile chromophore and a 113 amino acid apoprotein to which the chromophore is tightly and non-covalently bound with high affinity. The chromophore is a very potent DNA-damaging agent; it is very labile and the role of the apoprotein is to protect it and release it to the target DNA. Opening of the epoxide under reductive conditions present in cells creates favorable conditions for a Bergman cyclization, leading to a diradical intermediate and eventually double DNA strand cleavage. Other members of the neocarzinostatin group of antibiotics are macromomycin, actinoxanthin, kedarcidin and maduropeptin. As a medicine it is among the most potent, and in Japan only it has been used against liver cancer clinically.
Numerology
Chaldean Numerology
The numerical value of neocarzinostatin in Chaldean Numerology is: 7
Pythagorean Numerology
The numerical value of neocarzinostatin in Pythagorean Numerology is: 5
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"neocarzinostatin." Definitions.net. STANDS4 LLC, 2024. Web. 25 Apr. 2024. <https://www.definitions.net/definition/neocarzinostatin>.
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