Definitions for necrosisnəˈkroʊ sɪs
This page provides all possible meanings and translations of the word necrosis
Random House Webster's College Dictionary
death of a circumscribed portion of animal or plant tissue.
Origin of necrosis:
1655–65; < NL < Gk nékrōsis state of death = nekrō-, var. s. of nekroûn to kill, mortify
nec•ro•tizeˈnɛk rəˌtaɪz(v.i.; v.t.)
necrosis, mortification, gangrene, sphacelus(noun)
the localized death of living cells (as from infection or the interruption of blood supply)
The localized death of cells or tissues through injury, disease, or the interruption of blood supply.
Origin: From νέκρωσις.
mortification or gangrene of bone, or the death of a bone or portion of a bone in mass, as opposed to its death by molecular disintegration. See Caries
a disease of trees, in which the branches gradually dry up from the bark to the center
Necrosis is a form of cell injury that results in the premature death of cells in living tissue. Necrosis is caused by factors external to the cell or tissue, such as infection, toxins, or trauma that result in the unregulated digestion of cell components. In contrast, apoptosis is a naturally occurring programmed and targeted cause of cellular death. While apoptosis often provides beneficial effects to the organism, necrosis is almost always detrimental and can be fatal. Cells that die due to necrosis do not follow the apoptotic signal transduction pathway but rather various receptors are activated that result in the loss of cell membrane integrity and an uncontrolled release of products of cell death into the intracellular space. This initiates an inflammatory response in the surrounding tissue: Nearby phagocytes are prevented from locating and engulfing the dead cells. The result is a build-up of dead tissue and cell debris at, or near, the site of the cell death. A classic example is gangrene. For this reason, it is often necessary to remove necrotic tissue surgically, a process known as debridement.
U.S. National Library of Medicine
The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. Distinguish it from APOPTOSIS which is a normal, regulated cellular process.
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