Definitions for nalidixic acid
nalidix·ic acid

Princeton's WordNetRate this definition:0.0 / 0 votes

1. nalidixic acid, NegGramnoun

   antibacterial agent used especially to treat genitourinary infections

WiktionaryRate this definition:0.0 / 0 votes

1. nalidixic acidnoun

   A quinolone antibiotic used to treat infections of the genital and urinary tracts.

ChatGPTRate this definition:0.0 / 0 votes

1. nalidixic acid

   Nalidixic acid is a synthetic chemotherapeutic antibacterial agent that is used to fight bacteria in the body. It is the prototype of the synthetic quinolone antibiotics. It is generally used to treat urinary tract infections caused by certain bacteria. As an antibiotic, it works by killing sensitive bacteria by interfering with the enzymes needed for DNA replication.

WikidataRate this definition:0.0 / 0 votes

1. Nalidixic acid

   Nalidixic acid is the first of the synthetic quinolone antibiotics. In the technical sense, it is a naphthyridone, not a quinolone: its ring structure is a 1,8-naphthyridine nucleus that contains two nitrogen atoms, unlike quinoline, which has a single nitrogen atom. Synthetic quinolone antibiotics were discovered by George Lesher and coworkers as a byproduct of chloroquine manufacture in the 1960s. Used clinically from 1967. Nalidixic acid is effective against both Gram-positive and Gram-negative bacteria. In lower concentrations, it acts in a bacteriostatic manner; that is, it inhibits growth and reproduction. In higher concentrations, it is bactericidal, meaning that it kills bacteria instead of merely inhibiting their growth. It has historically been used for treating urinary tract infections, caused, for example, by Escherichia coli, Proteus, Shigella, Enterobacter, and Klebsiella. It is no longer clinically used for this indication in the USA as less toxic and more effective agents are available. It is also a tool in studies as a regulation of bacterial division. It selectively and reversibly blocks DNA replication in susceptible bacteria. Nalidixic acid and related antibiotics inhibit a subunit of DNA gyrase and induce formation of relaxation complex analogue. It also inhibits the nicking dosing activity on the subunit of DNA gyrase that releases the positive binding stress on the supercoiled DNA.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Nalidixic Acid

   A synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA GYRASE.

Matched Categories

1. • Antibacterial

How to pronounce nalidixic acid?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say nalidixic acid in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of nalidixic acid in Chaldean Numerology is: 6

2. Pythagorean Numerology

   The numerical value of nalidixic acid in Pythagorean Numerology is: 3

References

1. ^ Princeton's WordNet
   http://wordnetweb.princeton.edu/perl/webwn?s=nalidixic acid
2. ^ Wiktionary
   https://en.wiktionary.org/wiki/Nalidixic_Acid
3. ^ ChatGPT
   https://chat.openai.com
4. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=nalidixic acid