Definitions for nalidixic acid

This page provides all possible meanings and translations of the word nalidixic acid

Princeton's WordNetRate this definition:(0.00 / 0 votes)

  1. nalidixic acid, NegGram(noun)

    antibacterial agent used especially to treat genitourinary infections

WiktionaryRate this definition:(0.00 / 0 votes)

  1. nalidixic acid(Noun)

    A quinolone antibiotic used to treat infections of the genital and urinary tracts.

FreebaseRate this definition:(0.00 / 0 votes)

  1. Nalidixic acid

    Nalidixic acid is the first of the synthetic quinolone antibiotics. In the technical sense, it is a naphthyridone, not a quinolone: its ring structure is a 1,8-naphthyridine nucleus that contains two nitrogen atoms, unlike quinoline, which has a single nitrogen atom. Synthetic quinolone antibiotics were discovered by George Lesher and coworkers as a byproduct of chloroquine manufacture in the 1960s. Used clinically from 1967. Nalidixic acid is effective against both Gram-positive and Gram-negative bacteria. In lower concentrations, it acts in a bacteriostatic manner; that is, it inhibits growth and reproduction. In higher concentrations, it is bactericidal, meaning that it kills bacteria instead of merely inhibiting their growth. It has historically been used for treating urinary tract infections, caused, for example, by Escherichia coli, Proteus, Shigella, Enterobacter, and Klebsiella. It is no longer clinically used for this indication in the USA as less toxic and more effective agents are available. It is also a tool in studies as a regulation of bacterial division. It selectively and reversibly blocks DNA replication in susceptible bacteria. Nalidixic acid and related antibiotics inhibit a subunit of DNA gyrase and induce formation of relaxation complex analogue. It also inhibits the nicking dosing activity on the subunit of DNA gyrase that releases the positive binding stress on the supercoiled DNA.

U.S. National Library of MedicineRate this definition:(0.00 / 0 votes)

  1. Nalidixic Acid

    A synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA GYRASE.

Translations for nalidixic acid

From our Multilingual Translation Dictionary

  • nalidiksiinihappoFinnish
  • налидиксовая кислотаRussian

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