nalidixic acid, NegGram(noun)
antibacterial agent used especially to treat genitourinary infections
A quinolone antibiotic used to treat infections of the genital and urinary tracts.
Nalidixic acid is the first of the synthetic quinolone antibiotics. In the technical sense, it is a naphthyridone, not a quinolone: its ring structure is a 1,8-naphthyridine nucleus that contains two nitrogen atoms, unlike quinoline, which has a single nitrogen atom. Synthetic quinolone antibiotics were discovered by George Lesher and coworkers as a byproduct of chloroquine manufacture in the 1960s. Used clinically from 1967. Nalidixic acid is effective against both Gram-positive and Gram-negative bacteria. In lower concentrations, it acts in a bacteriostatic manner; that is, it inhibits growth and reproduction. In higher concentrations, it is bactericidal, meaning that it kills bacteria instead of merely inhibiting their growth. It has historically been used for treating urinary tract infections, caused, for example, by Escherichia coli, Proteus, Shigella, Enterobacter, and Klebsiella. It is no longer clinically used for this indication in the USA as less toxic and more effective agents are available. It is also a tool in studies as a regulation of bacterial division. It selectively and reversibly blocks DNA replication in susceptible bacteria. Nalidixic acid and related antibiotics inhibit a subunit of DNA gyrase and induce formation of relaxation complex analogue. It also inhibits the nicking dosing activity on the subunit of DNA gyrase that releases the positive binding stress on the supercoiled DNA.
U.S. National Library of Medicine
A synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA GYRASE.
The numerical value of nalidixic acid in Chaldean Numerology is: 6
The numerical value of nalidixic acid in Pythagorean Numerology is: 3
Images & Illustrations of nalidixic acid
Translations for nalidixic acid
From our Multilingual Translation Dictionary
Get even more translations for nalidixic acid »
Find a translation for the nalidixic acid definition in other languages:
Select another language:
Discuss these nalidixic acid definitions with the community:
Word of the Day
Would you like us to send you a FREE new word definition delivered to your inbox daily?
Use the citation below to add this definition to your bibliography:
"nalidixic acid." Definitions.net. STANDS4 LLC, 2017. Web. 26 May 2017. <http://www.definitions.net/definition/nalidixic acid>.