Definitions for multiple myeloma
Random House Webster's College Dictionary
a malignant plasma cell tumor of the bone marrow that destroys bone tissue.
Origin of multiple myeloma:
myeloma that develops in several places at the same time
A cancer of the white blood cells.
Multiple myeloma, also known as plasma cell myeloma or Kahler's disease, is a cancer of plasma cells, a type of white blood cell normally responsible for producing antibodies. In multiple myeloma, collections of abnormal plasma cells accumulate in the bone marrow, where they interfere with the production of normal blood cells. Most cases of myeloma also feature the production of a paraprotein—an abnormal antibody which can cause kidney problems. Bone lesions and hypercalcemia are also often encountered. Myeloma is diagnosed with blood tests, bone marrow examination, urine protein electrophoresis, and X-rays of commonly involved bones. Myeloma is generally thought to be treatable but incurable. Remissions may be induced with steroids, chemotherapy, proteasome inhibitors, immunomodulatory drugs such as thalidomide or lenalidomide, and stem cell transplants. Radiation therapy is sometimes used to reduce pain from bone lesions. Myeloma develops in 1–4 per 100,000 people per year. It is more common in men, and for unknown reasons is twice as common in African-Americans as it is in European-Americans. With conventional treatment, median survival is 3–4 years, which may be extended to 5–7 years or longer with advanced treatments. Multiple myeloma is the second most common hematological malignancy in the U.S., and constitutes 1% of all cancers.
U.S. National Library of Medicine
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
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"multiple myeloma." Definitions.net. STANDS4 LLC, 2013. Web. 4 Dec. 2013. <http://www.definitions.net/definition/multiple myeloma>.