What does mitotane mean?
Definitions for mitotane
mi·totane
This dictionary definitions page includes all the possible meanings, example usage and translations of the word mitotane.
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Wiktionary
mitotanenoun
A particular oral drug used to treat cancer.
Wikipedia
Mitotane
Mitotane, sold under the brand name Lysodren, is a steroidogenesis inhibitor and cytostatic antineoplastic medication which is used in the treatment of adrenocortical carcinoma and Cushing's syndrome. It is a derivative of the early insecticide DDT and an isomer of p,p'-DDD (4,4'-dichlorodiphenyldichloroethane) and is also known as 2,4'-(dichlorodiphenyl)-2,2-dichloroethane (o,p'-DDD).
Wikidata
Mitotane
Mitotane, also known as o,p'-DDD, is an antineoplastic medication used in the treatment of adrenocortical carcinoma. It is an isomer of DDD and is a derivative of DDT. Its main use is in those patients who have persistent disease despite surgical resection, those who are not surgical candidates, or those who have metastatic disease. It has been produced by Bristol Myers Squibb SpA but it is marketed as an orphan drug due to the small number of patients in need of it. A 2007 study of 177 patients shows a significant increase in the recurrence-free interval after radical surgery followed by mitotane when compared to surgery alone. Mitotane alters steroid peripheral metabolism, directly suppresses the adrenal cortex and alters cortisone metabolism leading to hypocortisolism. Side effects as reported by Schteinberg et al. include anorexia and nausea, diarrhea, vomiting, decreased memory and ability to concentrate, rash, gynecomastia, arthralgia, and leukopenia. Its trade name is Lysodren.
U.S. National Library of Medicine
Mitotane
A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
Anagrams for mitotane »
tomatine
Numerology
Chaldean Numerology
The numerical value of mitotane in Chaldean Numerology is: 4
Pythagorean Numerology
The numerical value of mitotane in Pythagorean Numerology is: 7
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"mitotane." Definitions.net. STANDS4 LLC, 2024. Web. 23 Apr. 2024. <https://www.definitions.net/definition/mitotane>.
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