Definitions for milrinone
mil·ri·none

WiktionaryRate this definition:0.0 / 0 votes

1. milrinonenoun

   An inhibitor of phosphodiesterase III that potentiates the effect of cyclic adenosine monophosphate.

WikipediaRate this definition:0.0 / 0 votes

1. Milrinone

   Milrinone, sold under the brand name Primacor, is a pulmonary vasodilator used in patients who have heart failure. It is a phosphodiesterase 3 inhibitor that works to increase the heart's contractility and decrease pulmonary vascular resistance. Milrinone also works to vasodilate which helps alleviate increased pressures (afterload) on the heart, thus improving its pumping action. While it has been used in people with heart failure for many years, studies suggest that milrinone may exhibit some negative side effects that have caused some debate about its use clinically.Overall, milrinone supports ventricular functioning of the heart by decreasing the degradation of cyclic adenosine monophosphate (cAMP) and thus increasing phosphorylation levels of many components in the heart that contribute to contractility and heart rate. Milrinone is used as a drug that causes positive inotropy and it will lead to an increased force of contraction. Milrinone use following cardiac surgery has been under some debate because of the potential increase risk of postoperative atrial arrhythmias. However, in the short term milrinone has been deemed beneficial to those experiencing heart failure and an effective therapy to maintain heart function following cardiac surgeries. There is no evidence of any long term beneficial effects on survival. In critically ill patients with evidence of cardiac dysfunction there is limited good quality evidence to recommend its use.Milrinone is administered IV only and eliminated unchanged in the urine. Dose adjustment is required for patients with renal impairment.

WikidataRate this definition:0.0 / 0 votes

1. Milrinone

   Milrinone, commonly known and marketed as the drug Primacor, is a medication used in patients suffering from heart failure. Milrinone is a phosphodiesterase 3 inhibitor that works to increase the heart's contractility. Milrinone also works to vasodilate vessels which helps alleviate increased pressures on the heart, thus improving its pumping action. Milrinone has been used in those suffering from heart failure for many years. However, in recent studies the drug has been shown to exhibit some negative side effects that have caused some debate about its use clinically.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Milrinone

   A positive inotropic cardiotonic agent with vasodilator properties. It inhibits cAMP phosphodiesterase activity in myocardium and vascular smooth muscle. Milrinone is a derivative of amrinone and has 20-30 times the ionotropic potency of amrinone.

How to pronounce milrinone?

1. Alex

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   David

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   Mark

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   Daniel

   British

   Libby

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   Mia

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   Karen

   Australian

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   Neerja

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   Zira

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   Oliver

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Numerology

1. Chaldean Numerology

   The numerical value of milrinone in Chaldean Numerology is: 6

2. Pythagorean Numerology

   The numerical value of milrinone in Pythagorean Numerology is: 1

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References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Milrinone
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Milrinone
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=milrinone