What does microcarrier mean?
Definitions for microcarrier
mi·cro·car·ri·er
This dictionary definitions page includes all the possible meanings, example usage and translations of the word microcarrier.
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Wiktionary
microcarriernoun
Small, beadlike material used to immobilize biocatalysts, or to anchor growing cells
Wikipedia
Microcarrier
A microcarrier is a support matrix that allows for the growth of adherent cells in bioreactors. Instead of on a flat surface, cells are cultured on the surface of spherical microcarriers so that each particle carries several hundred cells, and therefore expansion capacity can be multiplied several times over. It provides a straightforward way to scale up culture systems for industrial production of cell or protein-based therapies, or for research purposes.These solid or porous spherical matrices range anywhere between 100-300 um in diameter to allow sufficient surface area while retaining enough cell adhesion and support, and their density is minimally above that of water (1 g/ml) so that they remain in suspension in a stirred tank. They can be composed of either synthetic materials such as acrylamide or natural materials such as gelatin.The advantages of microcarrier technology in the biotech industry include (a) ease of scale-up, (b) ability to precisely control cell growth conditions in sophisticated, computer-controlled bioreactors, (c) an overall reduction in the floor space and incubator volume required for a given-sized manufacturing operation, (d) a drastic reduction in technician labor, and (e) a more natural environment for cell culture that promotes differentiation.
Wikidata
Microcarrier
A microcarrier is a support matrix allowing for the growth of adherent cells in bioreactors. In 1967, microcarrier development began when van Wezel found that microcarriers could support the growth of anchorage-dependent cells.[1] Microcarriers are typically 125 - 250 micrometre spheres and their density allows them to be maintained in suspension with gentle stirring. Microcarriers can be made from a number of different materials including DEAE-dextran, glass, polystyrene plastic, acrylamide, and collagen, and these microcarrier materials, along with different surface chemistries, can influence cellular behavior, including morphology and proliferation.[2-5] Surface chemistries can include extracellular matrix proteins, recombinant proteins, peptides, and positively or negatively charged molecules. Microcarriers are regularly used to grow protein-producing or virus-generating adherent cell populations in the large-scale commercial production of biologics and vaccines. Microcarrier cell culture is typically carried out in spinner flasks, although other vessels such as rotating wall microgravity bioreactors or fluidized bed bioreactors can also support microcarrier-based cultures. The advantages of microcarrier technology in the vaccine industry include ease of scale-up, ability to precisely control cell growth conditions in sophisticated, computer-controlled bioreactors, an overall reduction in the floor space and incubator volume required for a given-sized manufacturing operation, and a drastic reduction in technician labor.
Numerology
Chaldean Numerology
The numerical value of microcarrier in Chaldean Numerology is: 6
Pythagorean Numerology
The numerical value of microcarrier in Pythagorean Numerology is: 4
Translations for microcarrier
From our Multilingual Translation Dictionary
- microcarrierLatin
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"microcarrier." Definitions.net. STANDS4 LLC, 2024. Web. 19 Mar. 2024. <https://www.definitions.net/definition/microcarrier>.
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