Definitions for mevastatin
mev·as·tatin

WiktionaryRate this definition:0.0 / 0 votes

1. mevastatinnoun

   A statin, produced by the mould Penicillium citrinum, used in the production of pravastatin

WikipediaRate this definition:0.0 / 0 votes

1. Mevastatin

   Mevastatin (compactin, ML-236B) is a hypolipidemic agent that belongs to the statins class. It was isolated from the mold Penicillium citrinum by Akira Endo in the 1970s, and he identified it as a HMG-CoA reductase inhibitor, i.e., a statin. Mevastatin might be considered the first statin drug; clinical trials on mevastatin were performed in the late 1970s in Japan, but it was never marketed. The first statin drug available to the general public was lovastatin. Mevastatin has since been derivatized to the compound pravastatin, which is a pharmaceutical used in the lowering of cholesterol and preventing cardiovascular disease. In vitro, it has antiproliferative properties.A British group isolated the same compound from Penicillium brevicompactum, named it compactin, and published their results in 1976. The British group mentions antifungal properties with no mention of HMG-CoA reductase inhibition. High doses inhibit growth and proliferation of melanoma cells.

WikidataRate this definition:0.0 / 0 votes

1. Mevastatin

   Mevastatin, compactin, ML-236B is a hypolipidemic agent that belongs to the statins class. It was isolated from the mold Penicillium citrinum by Akira Endo in the 1970s and he identified it as a HMG-CoA reductase inhibitor, i.e.; a statin. Mevastatin might be considered the first statin drug, but, although clinical trials on mevastatin were performed in the late 1970s in Japan, it was never marketed.The first statin drug available to the general public was lovastatin. In vitro it has antiproliferative properties. A British group isolated the same compound from Penicillium brevicompactum, named it compactin and also published it in 1976. The British group mentions anti-fungal properties with no mention of HMG-CoA Reductase inhibition. High doses inhibit growth and proliferation of melanoma cells.

How to pronounce mevastatin?

1. Alex

   US English

   David

   US English

   Mark

   US English

   Daniel

   British

   Libby

   British

   Mia

   British

   Karen

   Australian

   Hayley

   Australian

   Natasha

   Australian

   Veena

   Indian

   Priya

   Indian

   Neerja

   Indian

   Zira

   US English

   Oliver

   British

   Wendy

   British

   Fred

   US English

   Tessa

   South African

How to say mevastatin in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of mevastatin in Chaldean Numerology is: 7

2. Pythagorean Numerology

   The numerical value of mevastatin in Pythagorean Numerology is: 7

References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Mevastatin
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Mevastatin
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=mevastatin