Definitions for maprotiline

This page provides all possible meanings and translations of the word maprotiline


  1. maprotiline(Noun)

    A tetracyclic antidepressant with sedative, anxiolytic, sympathomimetic and anticholinergic properties.


  1. Maprotiline

    Maprotiline is a tetracyclic antidepressant. However, Maprotiline's fourth ring is spurious, as formed by a bridge across the central tricyclic ring. It is a strong norepinephrine reuptake inhibitor with only weak effects on serotonin and dopamine reuptake. It exerts blocking effects at the following postsynaptic receptors: ⁕Strong : H1 ⁕Moderate : 5-HT2, alpha1 ⁕Weak : D2, mACh The pharmacologic profile of Maprotiline explains its antidepressant, sedative, anxiolytic, and sympathomimetic activities. Additionally, it shows a strong antagonism against Reserpine-induced effects in animal studies, as do the other 'classical' antidepressants. Although Maprotiline behaves in most regards as a 'first generation antidepressant' it is commonly referred to as 'second generation antidepressant'.

U.S. National Library of Medicine

  1. Maprotiline

    A bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use.


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