1. (verb) unstuff, loosen up
cause to become unblocked
"The medicine unstuffed my nose in minutes!"
2. (verb) relax, loosen up
become less tense, less formal, or less restrained, and assume a friendlier manner
"our new colleague relaxed when he saw that we were a friendly group"
3. (verb) limber up, warm up, loosen up
make one's body limber or suppler by stretching, as if to prepare for strenuous physical activity
4. (verb) relax, loosen up, unbend, unwind, decompress, slow down
become less tense, rest, or take one's ease
"He relaxed in the hot tub"; "Let's all relax after a hard day's work"
5. (verb) relax, unstrain, unlax, loosen up, unwind, make relaxed
cause to feel relaxed
"A hot bath always relaxes me"
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Definitions of loosen up 
