Definitions for keratoacanthoma
This page provides all possible meanings and translations of the word keratoacanthoma
skin tumor that grows rapidly (especially in older people) and resembles a carcinoma but does not spread; it usually disappears spontaneously, often leaving a scar
A common low-grade malignancy of the skin.
Keratoacanthoma is a common low-grade skin tumour that is believed to originate from the neck of the hair follicle. Many pathologists consider it to be a form of squamous cell carcinoma. The pathologist often labels KA as "well-differentiated squamous cell carcinoma, keratoacanthoma variant", because about 6% of KA manifest itself as squamous cell carcinoma when left untreated. KA is commonly found on sun-exposed skin, and often is seen on the face, forearms and hands. The defining characteristic of KA is that it is dome-shaped, symmetrical, surrounded by a smooth wall of inflamed skin, and capped with keratin scales and debris. It always grows rapidly, reaching a large size within days or weeks, and if untreated will starve itself of nourishment, necrose, slough, and heal with scarring. While some pathologists classify KA as a distinct tumor and not a malignancy, enough clinical and histological KA do progress to invasive and aggressive squamous cell cancers, therefore prompt and aggressive treatment is required. In reality, the defining characteristics of a KA can not be found when only a small fragment of a large KA is submitted for pathology review. If the keratin debris is submitted, no diagnosis can be made. If a deep core or peripheral deep wedge is performed, a squamous cell carcinoma is often noted. Only when almost the entire structure is submitted, can a true diagnosis of a KA be made. This further complicates the distinction between a clinical diagnosis of a KA and the pathologic diagnosis of a KA vs a squamous cell cancer.
U.S. National Library of Medicine
A benign, non-neoplastic, usually self-limiting epithelial lesion closely resembling squamous cell carcinoma clinically and histopathologically. It occurs in solitary, multiple, and eruptive forms. The solitary and multiple forms occur on sunlight exposed areas and are identical histologically; they affect primarily white males. The eruptive form usually involves both sexes and appears as a generalized papular eruption.
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"keratoacanthoma." Definitions.net. STANDS4 LLC, 2015. Web. 30 May 2015. <http://www.definitions.net/definition/keratoacanthoma>.