Definitions for kanamycin kinase
kanamycin ki·nase

WikipediaRate this definition:0.0 / 0 votes

1. Kanamycin kinase

   Aminoglycoside-3'-phosphotransferase (APH(3')), also known as aminoglycoside kinase, is an enzyme that primarily catalyzes the addition of phosphate from ATP to the 3'-hydroxyl group of a 4,6-disubstituted aminoglycoside, such as kanamycin. However, APH(3') has also been found to phosphorylate at the 5'-hydroxyl group in 4,5-disubstituted aminoglycosides, which lack a 3'-hydroxyl group, and to diphosphorylate hydroxyl groups in aminoglycosides that have both 3'- and 5'-hydroxyl groups. Primarily positively charged at biological conditions, aminoglycosides bind to the negatively charged backbone of nucleic acids to disrupt protein synthesis, effectively inhibiting bacterial cell growth. APH(3') mediated phosphorylation of aminoglycosides effectively disrupts their mechanism of action, introducing a phosphate group that reduces their binding affinity due to steric hindrances and unfavorable electrostatic interactions. APH(3') is primarily found in certain species of gram-positive bacteria. This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:kanamycin 3'-O-phosphotransferase. This enzyme is also called neomycin-kanamycin phosphotransferase.

WikidataRate this definition:0.0 / 0 votes

1. Kanamycin kinase

   In enzymology, a kanamycin kinase is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are ATP and kanamycin, whereas its two products are ADP and kanamycin 3'-phosphate. This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:kanamycin 3'-O-phosphotransferase. This enzyme is also called neomycin-kanamycin phosphotransferase.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Kanamycin Kinase

   A class of enzymes that inactivate aminocyclitol-aminoglycoside antibiotics (AMINOGLYCOSIDES) by regiospecific PHOSPHORYLATION of the 3' and/or 5' hydroxyl.

How to pronounce kanamycin kinase?

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Numerology

1. Chaldean Numerology

   The numerical value of kanamycin kinase in Chaldean Numerology is: 4

2. Pythagorean Numerology

   The numerical value of kanamycin kinase in Pythagorean Numerology is: 6

References

1. ^ Wikipedia
   https://en.wikipedia.org/wiki/Kanamycin_Kinase
2. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=kanamycin kinase