Definitions for janus kinase 2
janus ki·nase 2

WikipediaRate this definition:0.0 / 0 votes

1. Janus kinase 2

   Janus kinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase. It is a member of the Janus kinase family and has been implicated in signaling by members of the type II cytokine receptor family (e.g. interferon receptors), the GM-CSF receptor family (IL-3R, IL-5R and GM-CSF-R), the gp130 receptor family (e.g., IL-6R), and the single chain receptors (e.g. Epo-R, Tpo-R, GH-R, PRL-R).The distinguishing feature between janus kinase 2 and other JAK kinases is the lack of Src homology binding domains (SH2/SH3) and the presence of up to seven JAK homology domains (JH1-JH7). Nonetheless the terminal JH domains retain a high level of homology to tyrosine kinase domains. An interesting note is that only one of these carboxy-terminal JH domains retains full kinase function (JH1) while the other (JH2), previously thought to have no kinase functionality and accordingly termed a pseudokinase domain, has since been found to be catalytically active, albeit at only 10% that of the JH1 domain.Loss of Jak2 is lethal by embryonic day 12 in mice.JAK2 orthologs have been identified in all mammals for which complete genome data are available.

WikidataRate this definition:0.0 / 0 votes

1. Janus kinase 2

   Janus kinase 2 is a non-receptor tyrosine kinase. It is a member of the Janus kinase family and has been implicated in signaling by members of the type II cytokine receptor family, the GM-CSF receptor family, the gp130 receptor family, and the single chain receptors. JAK2 signaling is activated downstream from the prolactin receptor. Loss of Jak2 is lethal by embryonic day 12 in mice. JAK2 orthologs have been identified in all mammals for which complete genome data are available.

U.S. National Library of MedicineRate this definition:0.0 / 0 votes

1. Janus Kinase 2

   A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS.

How to pronounce janus kinase 2?

1. Alex

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Numerology

1. Chaldean Numerology

   The numerical value of janus kinase 2 in Chaldean Numerology is: 6

2. Pythagorean Numerology

   The numerical value of janus kinase 2 in Pythagorean Numerology is: 7

References

1. ^ Wikipedia
   https://en.wikipedia.org/wiki/Janus_Kinase_2
2. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=janus kinase 2