Janus kinase 2
Janus kinase 2 is a non-receptor tyrosine kinase. It is a member of the Janus kinase family and has been implicated in signaling by members of the type II cytokine receptor family, the GM-CSF receptor family, the gp130 receptor family, and the single chain receptors. JAK2 signaling is activated downstream from the prolactin receptor. Loss of Jak2 is lethal by embryonic day 12 in mice. JAK2 orthologs have been identified in all mammals for which complete genome data are available.
U.S. National Library of Medicine
Janus Kinase 2
A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS.
The numerical value of janus kinase 2 in Chaldean Numerology is: 6
The numerical value of janus kinase 2 in Pythagorean Numerology is: 7
Images & Illustrations of janus kinase 2
Translations for janus kinase 2
From our Multilingual Translation Dictionary
Get even more translations for janus kinase 2 »
Find a translation for the janus kinase 2 definition in other languages:
Select another language:
Discuss these janus kinase 2 definitions with the community:
Word of the Day
Would you like us to send you a FREE new word definition delivered to your inbox daily?
Use the citation below to add this definition to your bibliography:
"janus kinase 2." Definitions.net. STANDS4 LLC, 2018. Web. 23 Jan. 2018. <http://www.definitions.net/definition/janus kinase 2>.