Definitions of immunoglobulin joining region

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Definition of 'immunoglobulin joining region'

U.S. National Library of Medicine

1. immunoglobulin joining region
A segment of the immunoglobulin heavy chains, encoded by the IMMUNOGLOBULIN HEAVY CHAIN GENES in the J segment where, during the maturation of B-LYMPHOCYTES; the gene segment for the variable region upstream is joined to a constant region gene segment downstream. The exact position of joining of the two gene segments is variable and contributes to ANTIBODY DIVERSITY. It is distinguished from the IMMUNOGLOBULIN J CHAINS; a separate polypeptide that serves as a linkage piece in polymeric IGA or IGM.

'immunoglobulin joining region' - Nearby Entries
immunoglobulin isotypes immunoglobulin j recombination signal sequence-binding protein immunoglobulin j-chains immunoglobulin joining region immunoglobulin kappa-chains immunoglobulin km allotypes immunoglobulin lambda-chains

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