Definitions for ibogaine
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A naturally-occurring psychoactive compound found in a number of plants, principally iboga, and used for medicinal and ritual purposes in African spiritual traditions of the Bwiti.
Ibogaine is a naturally occurring psychoactive substance found in a plant in a member of the Apocynaceae family known as Iboga. A hallucinogen with both psychedelic and dissociative properties, the substance is banned in some countries; in other countries it is being used to treat addiction to methadone, heroin, alcohol, cocaine, methamphetamine, and other drugs. Derivatives of ibogaine that lack the substance's hallucinogenic properties are under development. Ibogaine-containing preparations are used in medicinal and ritual purposes within African spiritual traditions of the Bwiti, who claim to have learned it from the Pygmy peoples. Although it was first commonly advertised as having anti-addictive properties in 1962 by Howard Lotsof, its western use predates that by at least a century. In France it was marketed as Lambarene, a medical drug used as a stimulant. Additionally, the U.S. Central Intelligence Agency studied the effects of ibogaine in the 1950s. Ibogaine is an indole alkaloid that is obtained either by extraction from the iboga plant or by semi-synthesis from the precursor compound voacangine, another plant alkaloid. A full organic synthesis of ibogaine has been achieved. The synthesis process is too expensive and challenging to be used to produce a commercially significant yield. The synthesis was published with U.S. Patent 2,813,873 in 1956. The free base and the HBr salt have both been characterised by X-ray crystallography.
U.S. National Library of Medicine
One of several indole alkaloids extracted from Tabernanthe iboga, Baill. It has a complex pharmacological profile, and interacts with multiple systems of neurotransmission. Ibogaine has psychoactive properties and appears to modulate tolerance to opiates.
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