Definitions for hypoxanthine phosphoribosyltransferase

This page provides all possible meanings and translations of the word hypoxanthine phosphoribosyltransferase

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  1. Hypoxanthine Phosphoribosyltransferase

    An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or 6-mercaptopurine to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8.

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