Definitions for hyperphosphorylation

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Wiktionary

  1. hyperphosphorylation(Noun)

    The state of being fully phosphorylated, so that all potential phosphorylation sites are occupied

Freebase

  1. Hyperphosphorylation

    Hyperphosphorylation occurs when a biochemical with multiple phosphorylation sites is fully saturated. Hyperphosphorylation is one of the signalling mechanisms used by the cell to regulate mitosis. When these mechanisms fail, developmental problems or cancer are a likely outcome. The mechanism appears to be largely conserved throughout eukaryote species. The dynamics of mitosis are similar to a state machine. In a healthy cell, checkpoints between phases, permit a new phase to begin only when the previous phase is complete and successful. At these checkpoints, gatekeeper molecules block or allow events, depending on their level of phosphorylation. Kinases are responsible for adding phosphate groups and phosphatases for removing them. Cyclins are molecules that manage the timing of cell cycle events. Cyclin dependent kinases pair up with cyclins to become operational. Cyclins are named because they are created or destroyed at predetermined points within the cell cycle. Kinase inhibitors add another level of modulation. Kinase inhibitors are grouped into classes and are assigned not very descriptive acronyms. These include INKS for inhibitors of kinase, KIPS for kinase inhibitors and CKIPS for cyclin dependent kinases inhibitors.

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"hyperphosphorylation." Definitions.net. STANDS4 LLC, 2014. Web. 17 Apr. 2014. <http://www.definitions.net/definition/hyperphosphorylation>.

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