What does huntingtin mean?
Definitions for huntingtin
hunt·ingtin
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Wiktionary
huntingtinnoun
A protein whose polymorphism is associated with Huntington's chorea
Wikidata
Huntingtin
The huntingtin gene, also called HTT or HD gene, is the IT15 gene which codes for a protein called the huntingtin protein. The gene and its product are under heavy investigation as part of Huntington's disease clinical research. It is variable in its structure, as the many polymorphisms of the gene can lead to variable numbers of glutamine residues present in the protein. In its wild-type form, it contains 6-35 glutamine residues. However, in individuals affected by Huntington's disease, it contains greater than 36 glutamine residues. Its commonly used name is derived from this disease; previously, the IT15 label was commonly used. The mass of huntingtin protein is dependent largely on the number of glutamine residues it has, the predicted mass is around 350 kDa. Normal huntingtin is generally accepted to be 3144 amino acids in size. The exact function of this protein is not known, but it plays an important role in nerve cells. Within cells, huntingtin may be involved in signaling, transporting materials, binding proteins and other structures, and protecting against programmed cell death. The huntingtin protein is required for normal development before birth. It is expressed in many tissues in the body, with the highest levels of expression seen in the brain.
Numerology
Chaldean Numerology
The numerical value of huntingtin in Chaldean Numerology is: 3
Pythagorean Numerology
The numerical value of huntingtin in Pythagorean Numerology is: 1
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"huntingtin." Definitions.net. STANDS4 LLC, 2024. Web. 24 Apr. 2024. <https://www.definitions.net/definition/huntingtin>.
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