Definitions for guanylate kinase

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  1. Guanylate kinase

    In enzymology, a guanylate kinase is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are ATP and GMP, whereas its two products are ADP and GDP. This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups with a phosphate group as acceptor. This enzyme participates in purine metabolism. Guanylate kinase catalyzes the ATP-dependent phosphorylation of GMP into GDP. It is essential for recycling GMP and indirectly, cGMP. In prokaryotes, lower eukaryotes and in vertebrates, GK is a highly conserved monomeric protein of about 200 amino acids. GK has been shown to be structurally similar to protein A57R from various strains of Vaccinia virus.

U.S. National Library of Medicine

  1. Guanylate Kinase

    Catalyzes the ATP-dependent PHOSPHORYLATION of GMP to generate GDP and ADP.

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