Definitions for genotoxicity
geno·tox·i·c·i·ty

WiktionaryRate this definition:0.0 / 0 votes

1. genotoxicitynoun

   The condition of being genotoxic.

2. genotoxicitynoun

   The relative toxicity of a genotoxin.

WikipediaRate this definition:0.0 / 0 votes

1. Genotoxicity

   Genotoxicity is the property of chemical agents that damage the genetic information within a cell causing mutations, which may lead to cancer. While genotoxicity is often confused with mutagenicity, all mutagens are genotoxic, but some genotoxic substances are not mutagenic. The alteration can have direct or indirect effects on the DNA: the induction of mutations, mistimed event activation, and direct DNA damage leading to mutations. The permanent, heritable changes can affect either somatic cells of the organism or germ cells to be passed on to future generations. Cells prevent expression of the genotoxic mutation by either DNA repair or apoptosis; however, the damage may not always be fixed leading to mutagenesis. To assay for genotoxic molecules, researchers assay for DNA damage in cells exposed to the toxic substrates. This DNA damage can be in the form of single- and double-strand breaks, loss of excision repair, cross-linking, alkali-labile sites, point mutations, and structural and numerical chromosomal aberrations. The compromised integrity of the genetic material has been known to cause cancer. As a consequence, many sophisticated techniques including Ames Assay, in vitro and in vivo Toxicology Tests, and Comet Assay have been developed to assess the chemicals' potential to cause DNA damage that may lead to cancer.

WikidataRate this definition:0.0 / 0 votes

1. Genotoxicity

   In genetics, genotoxicity describes the property of chemical agents that damages the genetic information within a cell causing mutations, which may lead to cancer. While genotoxicity is often confused with mutagenicity, it is important to note that all mutagens are genotoxic, however, not all genotoxic substances are mutagenic. The alteration can have direct or indirect effects on the DNA: the induction of mutations, mistimed event activation, and direct DNA damage leading to mutations. The permanent, hereditary changes can affect either somatic cells of the organism or germ cells to be passed on to future generations. Cells prevent expression of the genotoxic mutation by either DNA repair or apoptosis; however, the damage may not always be fixed leading to mutagenesis. To assay for genotoxic molecules, researchers assay for DNA damage in cells exposed to the toxic substrates. This DNA damage can be in the form of single and double strand breaks, loss of excision repair, cross-linking, alkali-labile sites, point mutations, and structural and numerical chromosomal aberrations. The compromised integrity of the genetic material has been known to cause cancer. Consequently, many sophisticated techniques including Ames Assay, in vitro and in vivo Toxicology Tests, and Comet Assay have been developed to assess the chemicals' potential to cause DNA damage that may lead to cancer.

How to pronounce genotoxicity?

1. Alex

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   Daniel

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   Australian

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How to say genotoxicity in sign language?

Numerology

1. Chaldean Numerology

   The numerical value of genotoxicity in Chaldean Numerology is: 1

2. Pythagorean Numerology

   The numerical value of genotoxicity in Pythagorean Numerology is: 4

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References

1. ^ Wiktionary
   https://en.wiktionary.org/wiki/Genotoxicity
2. ^ Wikipedia
   https://en.wikipedia.org/wiki/Genotoxicity
3. ^ Wikidata
   https://www.wikidata.org/w/index.php?search=genotoxicity