Definitions for gabazine

This page provides all possible meanings and translations of the word gabazine

Wiktionary

  1. gabazine(Noun)

    A drug that acts as an antagonist at GABA receptors

Freebase

  1. Gabazine

    Gabazine is a drug that acts as an antagonist at GABAA receptors. It is used in scientific research and has no role in medicine, as it would be expected to produce convulsions if used in humans. Gabazine binds to the GABA recognition site of the receptor-channel complex and acts as an allosteric inhibitor of channel opening. The net effect is to reduce GABA-mediated synaptic inhibition by inhibiting chloride flux across the cell membrane, and thus inhibiting neuronal hyperpolarization. While phasic inhibition is gabazine-sensitive, tonic inhibition is relatively gabazine-insensitive.

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