1. fibrinogens, abnormal Fibrinogens which have a functional defect as the result of one or more amino acid substitutions in the amino acid sequence of normalfibrinogen. Abnormalities of the fibrinogenmolecule may impair any of the major steps involved in the conversion of fibrinogen into stabilized fibrin, such as cleavage of the fibrinopeptides by thrombin, polymerization and cross-linking of fibrin. The resulting dysfibrinogenemias can be clinically silent or can be associated with bleeding, thrombosis or defective woundhealing.
Definitions of fibrinogens, abnormal
